{"name":"Rejestr Dowodów Aloha Fungi · Aloha Fungi Evidence Registry","doi":"10.5281/zenodo.22256328","doiUrl":"https://doi.org/10.5281/zenodo.22256328","zenodo":"https://zenodo.org/records/22256329","archive":{"conceptDoi":"10.5281/zenodo.22256328","zenodo":"https://zenodo.org/records/22256329","note":{"pl":"Stały DOI wskazuje zawsze najnowszą zarchiwizowaną wersję na Zenodo. Ten żywy plik może być nowszy niż archiwum (statusy badań są sprawdzane co tydzień).","en":"The concept DOI always resolves to the latest archived version on Zenodo. This live file may be newer than the archive (study statuses are checked weekly)."}},"description":{"pl":"Zebraliśmy badania naukowe o 11 gatunkach grzybów, które sprzedajemy: kto badał, na jakiej grupie, jakim typem badania, w którym roku. Każda pozycja ma PMID albo DOI, żeby można ją było sprawdzić samodzielnie.","en":"We collected the scientific studies on the 11 mushroom species we sell: who ran them, on which group, with which study design, in which year. Every entry has a PMID or DOI so you can verify it yourself."},"version":"2026-09-02","dateModified":"2026-09-02","license":"https://creativecommons.org/licenses/by/4.0/","licenseNote":{"pl":"Licencja CC BY 4.0 dotyczy zestawienia i opisów PL/EN. Metadane badań (PMID, DOI, autorzy, tytuły) należą do ich wydawców.","en":"CC BY 4.0 covers the compilation and the PL/EN descriptions. Study metadata (PMID, DOI, authors, titles) belong to their publishers."},"canonical":"https://alohafungi.com/nauka","creator":{"name":"Aloha Fungi","legalName":"ALOHA WEALTH AND WELLNESS Sp. z o.o.","url":"https://alohafungi.com"},"count":138,"studies":[{"key":"pmid-40959699","pmid":"40959699","doi":"10.3389/fnut.2025.1641246","url":"https://pubmed.ncbi.nlm.nih.gov/40959699/","permalink":"https://alohafungi.com/nauka#pmid-40959699","permalinkEn":"https://alohafungi.com/en/nauka#pmid-40959699","title":"Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review","author":"Menon A. et al.","year":2025,"journal":"Frontiers in Nutrition","species":["soplowka-jezowata"],"type":{"pl":"przegląd systematyczny","en":"systematic review"},"n":{"pl":"26 prac, w tym tylko 5 RCT · liczba osób: brak danych","en":"26 studies, including only 5 RCTs · number of people: not reported"},"evidenceLevel":"B","preclinical":false,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd zbierał badania nad stosowaniem Hericium erinaceus jako suplementu w kontekście funkcji poznawczych oraz raportowanych działań niepożądanych. Autorzy zaznaczyli, że działania niepożądane są w literaturze zwykle nieraportowane.","en":"The review collected studies on the use of Hericium erinaceus as a supplement in the context of cognitive function and reported adverse effects. The authors noted that adverse effects are usually not reported in the literature."},"sourceId":"2.1","status":"ok"},{"key":"pmid-18844328","pmid":"18844328","doi":"10.1002/ptr.2634","url":"https://pubmed.ncbi.nlm.nih.gov/18844328/","permalink":"https://alohafungi.com/nauka#pmid-18844328","permalinkEn":"https://alohafungi.com/en/nauka#pmid-18844328","title":"Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial","author":"Mori K. et al.","year":2009,"journal":"Phytotherapy Research","species":["soplowka-jezowata"],"type":{"pl":"RCT, podwójnie zaślepione, placebo","en":"RCT, double-blind, placebo-controlled"},"n":{"pl":"30 osób, 50 do 80 lat, Japonia","en":"30 people, 50 to 80 years, Japan"},"evidenceLevel":"C","preclinical":false,"placebo":true,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie sprawdzało wpływ przyjmowania Hericium erinaceus na wynik skali funkcji poznawczych w grupie 30 japońskich osób w wieku 50 do 80 lat z łagodnymi zaburzeniami poznawczymi. Bardzo mała próba z jednej populacji, różnice zanikały w ciągu 4 tygodni po odstawieniu.","en":"The study examined the effect of taking Hericium erinaceus on a cognitive function scale score in a group of 30 Japanese people aged 50 to 80 with mild cognitive impairment. Very small sample from a single population, the differences faded within 4 weeks after discontinuation."},"sourceId":"2.2","status":"ok"},{"key":"pmid-20834180","pmid":"20834180","doi":"10.2220/biomedres.31.231","url":"https://pubmed.ncbi.nlm.nih.gov/20834180/","permalink":"https://alohafungi.com/nauka#pmid-20834180","permalinkEn":"https://alohafungi.com/en/nauka#pmid-20834180","title":"Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake","author":"Nagano M. et al.","year":2010,"journal":"Biomedical Research","species":["soplowka-jezowata"],"type":{"pl":"RCT, podwójnie zaślepione, placebo","en":"RCT, double-blind, placebo-controlled"},"n":{"pl":"30 kobiet","en":"30 women"},"evidenceLevel":"C","preclinical":false,"placebo":true,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie sprawdzało wpływ 4-tygodniowego przyjmowania Hericium erinaceus na wyniki kwestionariuszy dotyczących nastroju, objawów okołomenopauzalnych i jakości snu w grupie 30 kobiet. Próba bardzo mała, wyłącznie kobiety.","en":"The study examined the effect of 4 weeks of Hericium erinaceus intake on questionnaire scores for mood, perimenopausal symptoms and sleep quality in a group of 30 women. Very small sample, women only."},"sourceId":"2.3","status":"ok"},{"key":"pmid-31413233","pmid":"31413233","doi":"10.2220/biomedres.40.125","url":"https://pubmed.ncbi.nlm.nih.gov/31413233/","permalink":"https://alohafungi.com/nauka#pmid-31413233","permalinkEn":"https://alohafungi.com/en/nauka#pmid-31413233","title":"Improvement of cognitive functions by oral intake of Hericium erinaceus","author":"Saitsu Y. et al.","year":2019,"journal":"Biomedical Research","species":["soplowka-jezowata"],"type":{"pl":"RCT, podwójnie zaślepione, placebo","en":"RCT, double-blind, placebo-controlled"},"n":{"pl":"brak danych","en":"not reported"},"evidenceLevel":"C","preclinical":false,"placebo":true,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie sprawdzało wpływ 12-tygodniowego przyjmowania suplementu z owocnika Hericium erinaceus na wyniki testów funkcji poznawczych w grupie dorosłych uczestników. Autorzy zaznaczyli, że dowody dotyczące zdrowia człowieka pozostają niepewne.","en":"The study examined the effect of 12 weeks of taking a Hericium erinaceus fruiting-body supplement on cognitive function test results in a group of adult participants. The authors noted that evidence regarding human health remains uncertain."},"sourceId":"2.4","status":"ok"},{"key":"pmid-32581767","pmid":"32581767","doi":"10.3389/fnagi.2020.00155","url":"https://pubmed.ncbi.nlm.nih.gov/32581767/","permalink":"https://alohafungi.com/nauka#pmid-32581767","permalinkEn":"https://alohafungi.com/en/nauka#pmid-32581767","title":"Prevention of Early Alzheimer's Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Study","author":"Li I.C. et al.","year":2020,"journal":"Frontiers in Aging Neuroscience","species":["soplowka-jezowata"],"type":{"pl":"pilotażowe RCT, placebo","en":"pilot RCT, placebo-controlled"},"n":{"pl":"49 zrandomizowanych, 41 ukończyło","en":"49 randomised, 41 completed"},"evidenceLevel":"D","preclinical":false,"placebo":true,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie sprawdzało wpływ 49-tygodniowego przyjmowania grzybni Hericium erinaceus wzbogaconej w erinacynę A na wyniki testów poznawczych i parametry bezpieczeństwa u pacjentów z łagodną chorobą Alzheimera. Mały, pilotażowy rozmiar próby, potrzeba większych badań.","en":"The study examined the effect of 49 weeks of taking erinacine A-enriched Hericium erinaceus mycelia on cognitive test results and safety parameters in patients with mild Alzheimer's disease. Small, pilot sample size, larger studies needed."},"sourceId":"2.5","status":"ok"},{"key":"pmid-38004235","pmid":"38004235","doi":"10.3390/nu15224842","url":"https://pubmed.ncbi.nlm.nih.gov/38004235/","permalink":"https://alohafungi.com/nauka#pmid-38004235","permalinkEn":"https://alohafungi.com/en/nauka#pmid-38004235","title":"The Acute and Chronic Effects of Lion's Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study","author":"Docherty S. et al.","year":2023,"journal":"Nutrients","species":["soplowka-jezowata"],"type":{"pl":"pilotażowe RCT","en":"pilot RCT"},"n":{"pl":"41 zdrowych dorosłych","en":"41 healthy adults"},"evidenceLevel":"D","preclinical":false,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie sprawdzało wpływ jednorazowej dawki oraz 28-dniowej suplementacji Hericium erinaceus na wyniki testów poznawczych, poziom odczuwanego stresu i nastrój w grupie 41 zdrowych dorosłych. Mała próba, wyniki zerowe obok pozytywnych, potrzeba powtórzenia.","en":"The study examined the effect of a single dose and 28 days of Hericium erinaceus supplementation on cognitive test results, perceived stress and mood in a group of 41 healthy adults. Small sample, null results alongside positive ones, replication needed."},"sourceId":"2.6","status":"ok"},{"key":"pmid-40276537","pmid":"40276537","doi":"10.3389/fnut.2025.1405796","url":"https://pubmed.ncbi.nlm.nih.gov/40276537/","permalink":"https://alohafungi.com/nauka#pmid-40276537","permalinkEn":"https://alohafungi.com/en/nauka#pmid-40276537","title":"Acute effects of a standardised extract of Hericium erinaceus (Lion's Mane mushroom) on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled study","author":"Surendran G. et al.","year":2025,"journal":"Frontiers in Nutrition","species":["soplowka-jezowata"],"type":{"pl":"RCT naprzemienne, placebo, dawka jednorazowa","en":"crossover RCT, placebo-controlled, single dose"},"n":{"pl":"18 zdrowych dorosłych","en":"18 healthy adults"},"evidenceLevel":"C","preclinical":false,"placebo":true,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie sprawdzało wpływ jednorazowej dawki standaryzowanego ekstraktu z owocnika Hericium erinaceus na wyniki testów poznawczych i nastrój mierzone 90 minut po podaniu w grupie 18 zdrowych młodych dorosłych. Bardzo mała próba wymagająca replikacji.","en":"The study examined the effect of a single dose of a standardised Hericium erinaceus fruiting-body extract on cognitive test results and mood measured 90 minutes after administration in a group of 18 healthy young adults. Very small sample requiring replication."},"sourceId":"2.7","status":"ok"},{"key":"pmid-40626304","pmid":"40626304","doi":"10.3389/fphar.2025.1582081","url":"https://pubmed.ncbi.nlm.nih.gov/40626304/","permalink":"https://alohafungi.com/nauka#pmid-40626304","permalinkEn":"https://alohafungi.com/en/nauka#pmid-40626304","title":"Unveiling the role of erinacines in the neuroprotective effects of Hericium erinaceus: a systematic review in preclinical models","author":"Spangenberg E.T. et al.","year":2025,"journal":"Frontiers in Pharmacology","species":["soplowka-jezowata"],"type":{"pl":"przegląd systematyczny badań przedklinicznych","en":"systematic review of preclinical studies"},"n":{"pl":"nie dotyczy, 23 badania","en":"not applicable, 23 studies"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd zbierał badania przedkliniczne (in vitro i na gryzoniach) nad rolą erinacyn w modelach neuroprotekcji. Brak standaryzacji oznaczania erinacyn, niespójne raportowanie szczepów i metod ekstrakcji.","en":"The review collected preclinical studies (in vitro and in rodents) on the role of erinacines in neuroprotection models. No standardisation of erinacine measurement, inconsistent reporting of strains and extraction methods."},"sourceId":"2.8","status":"ok"},{"key":"doi-10-1016-0040-4039-91-80039-9","pmid":null,"doi":"10.1016/0040-4039(91)80039-9","url":"https://doi.org/10.1016/0040-4039(91)80039-9","permalink":"https://alohafungi.com/nauka#doi-10-1016-0040-4039-91-80039-9","permalinkEn":"https://alohafungi.com/en/nauka#doi-10-1016-0040-4039-91-80039-9","title":"Hericenones C, D and E, stimulators of nerve growth factor (NGF)-synthesis, from the mushroom Hericium erinaceum","author":"Kawagishi H. et al.","year":1991,"journal":"Tetrahedron Letters","species":["soplowka-jezowata"],"type":{"pl":"izolacja związków + test in vitro","en":"compound isolation + in vitro test"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Praca sprawdzała, poprzez izolację związków z owocnika i test in vitro, które substancje (hericenony C, D, E) stymulują syntezę czynnika wzrostu nerwów (NGF). Historyczna praca chemiczna (1991).","en":"The study examined, through compound isolation from the fruiting body and an in vitro test, which substances (hericenones C, D, E) stimulate nerve growth factor (NGF) synthesis. Historical chemistry paper (1991)."},"sourceId":"2.9","status":"unknown"},{"key":"pmid-26244378","pmid":"26244378","doi":"10.1021/acs.jafc.5b02914","url":"https://pubmed.ncbi.nlm.nih.gov/26244378/","permalink":"https://alohafungi.com/nauka#pmid-26244378","permalinkEn":"https://alohafungi.com/en/nauka#pmid-26244378","title":"Chemistry and Multibeneficial Bioactivities of a Potential Medicinal Mushroom, Hericium erinaceus","author":"Friedman M.","year":2015,"journal":"Journal of Agricultural and Food Chemistry","species":["soplowka-jezowata"],"type":{"pl":"przegląd narracyjny","en":"narrative review"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd narracyjny zbierał dane o składzie chemicznym, wartości odżywczej i zgłaszanych właściwościach zdrowotnych soplówki. Autor podkreśla, że wiele właściwości pochodzi z badań przedklinicznych.","en":"The narrative review collected data on the chemical composition, nutritional value and reported health properties of lion's mane. The author emphasises that many properties come from preclinical studies."},"sourceId":"2.10","status":"ok"},{"key":"pmid-24266378","pmid":"24266378","doi":"10.1615/intjmedmushr.v15.i6.30","url":"https://pubmed.ncbi.nlm.nih.gov/24266378/","permalink":"https://alohafungi.com/nauka#pmid-24266378","permalinkEn":"https://alohafungi.com/en/nauka#pmid-24266378","title":"In vitro study on cell culture and nerve fibre outgrowth","author":"Lai P.L. et al.","year":2013,"journal":"International Journal of Medicinal Mushrooms","species":["soplowka-jezowata"],"type":{"pl":"in vitro","en":"in vitro"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie sprawdzało wpływ wodnego ekstraktu na wzrost włókien nerwowych w hodowli komórkowej in vitro, samodzielnie i w połączeniu z NGF. Preparat nie chronił komórek przed uszkodzeniem oksydacyjnym mimo działania neurotroficznego.","en":"The study examined the effect of an aqueous extract on nerve fibre outgrowth in an in vitro cell culture, alone and combined with NGF. The preparation did not protect cells from oxidative damage despite its neurotrophic effect."},"sourceId":"2.11","status":"ok"},{"key":"pmid-14714963","pmid":"14714963","doi":"10.2169/internalmedicine.42.1219","url":"https://pubmed.ncbi.nlm.nih.gov/14714963/","permalink":"https://alohafungi.com/nauka#pmid-14714963","permalinkEn":"https://alohafungi.com/en/nauka#pmid-14714963","title":"A case of pneumonitis associated with medicinal mushroom (Hericium erinaceus)","author":"Nakatsugawa M. et al.","year":2003,"journal":"Internal Medicine","species":["soplowka-jezowata"],"type":{"pl":"opis przypadku, bezpieczeństwo","en":"case report, safety"},"n":{"pl":"1 pacjent, mężczyzna 63 lata","en":"1 patient, 63-year-old man"},"evidenceLevel":"D","preclinical":false,"placebo":null,"caseReport":true,"subspecies":null,"whatWasTested":{"pl":"Opis przypadku dokumentował ostrą niewydolność oddechową (zapalenie płuc) u 63-letniego mężczyzny po spożyciu ekstraktu z soplówki 4 miesiące wcześniej. Pojedynczy przypadek, dane z bezpieczeństwa, nie badanie skuteczności.","en":"The case report documented acute respiratory failure (pneumonitis) in a 63-year-old man after taking a lion's mane extract 4 months earlier. Single case, safety data, not an efficacy study."},"sourceId":"2.12","status":"ok"},{"key":"doi-10-64898-2026-04-13-26350781","pmid":null,"doi":"10.64898/2026.04.13.26350781","url":"https://www.medrxiv.org/content/10.64898/2026.04.13.26350781v1","permalink":"https://alohafungi.com/nauka#doi-10-64898-2026-04-13-26350781","permalinkEn":"https://alohafungi.com/en/nauka#doi-10-64898-2026-04-13-26350781","title":"Randomized, double-blind, placebo-controlled trial of Hericium erinaceus (preprint)","author":"Daoust J. et al.","year":2026,"journal":"medRxiv","species":["soplowka-jezowata"],"type":{"pl":"RCT, podwójnie zaślepione, placebo (preprint, brak recenzji)","en":"RCT, double-blind, placebo-controlled (preprint, not peer-reviewed)"},"n":{"pl":"109 osób (57+52), 40-75 lat, 8 tygodni","en":"109 people (57+52), 40-75 years, 8 weeks"},"evidenceLevel":"C","preclinical":false,"placebo":true,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie (preprint, nierecenzowany) sprawdzało wpływ 8-tygodniowej suplementacji 2 g dziennie biomasy owocnika i grzybni na testy uwagi wzrokowej, pamięci roboczej, jakość snu i nastrój u 109 dorosłych w wieku 40-75 lat ze zgłaszanymi trudnościami poznawczymi. Autorzy sami określają wyniki jako „skromne\". Status preprintu oznacza brak recenzji naukowej.","en":"The study (preprint, not peer-reviewed) examined the effect of 8 weeks of 2 g daily fruiting-body and mycelium biomass supplementation on visual attention, working memory, sleep quality and mood tests in 109 adults aged 40-75 with reported cognitive difficulties. The authors themselves describe the results as \"modest\". Preprint status means no scientific peer review."},"sourceId":"2.13","status":"unknown"},{"key":"doi-10-1017-s0954422425000058","pmid":null,"doi":"10.1017/S0954422425000058","url":"https://doi.org/10.1017/S0954422425000058","permalink":"https://alohafungi.com/nauka#doi-10-1017-s0954422425000058","permalinkEn":"https://alohafungi.com/en/nauka#doi-10-1017-s0954422425000058","title":"Hericium erinaceus: a possible future therapeutic treatment for the prevention and delayed progression of Alzheimer's disease: a narrative review","author":"Cornford N., Charnley M.","year":2025,"journal":"Nutrition Research Reviews","species":["soplowka-jezowata"],"type":{"pl":"przegląd narracyjny","en":"narrative review"},"n":{"pl":"nie dotyczy (3 badania na ludziach + 13 zwierzęce omówione w przeglądzie)","en":"not applicable (3 human studies + 13 animal studies discussed in the review)"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd narracyjny analizował 3 badania kliniczne na ludziach i 13 badań na zwierzętach dotyczących prewencji i opóźnienia postępu choroby Alzheimera. Autorzy wskazują na potrzebę dodatkowych badań klinicznych na ludziach.","en":"The narrative review analysed 3 human clinical studies and 13 animal studies on the prevention and delayed progression of Alzheimer's disease. The authors point to the need for additional human clinical studies."},"sourceId":"2.14","status":"unknown"},{"key":"pmid-27045603","pmid":"27045603","doi":"10.1002/14651858.CD007731.pub3","url":"https://pubmed.ncbi.nlm.nih.gov/27045603/","permalink":"https://alohafungi.com/nauka#pmid-27045603","permalinkEn":"https://alohafungi.com/en/nauka#pmid-27045603","title":"Ganoderma lucidum (Reishi mushroom) for cancer treatment","author":"Jin X. et al.","year":2016,"journal":"Cochrane Database of Systematic Reviews","species":["reishi"],"type":{"pl":"przegląd systematyczny Cochrane z metaanalizą","en":"Cochrane systematic review with meta-analysis"},"n":{"pl":"5 RCT, łączna liczba osób brak danych","en":"5 RCTs, total number of people not reported"},"evidenceLevel":"A","preclinical":false,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd zbierał badania z randomizacją nad stosowaniem Ganoderma lucidum w kontekście leczenia onkologicznego. Autorzy wskazali niezadowalającą jakość metodologiczną badań pierwotnych, niepełne raportowanie wyników, brak danych o przeżyciu długoterminowym oraz raportowanie zdarzeń niepożądanych tylko w jednym badaniu.","en":"The review collected randomised studies on the use of Ganoderma lucidum in the context of oncological treatment. The authors noted unsatisfactory methodological quality of the primary studies, incomplete outcome reporting, no long-term survival data, and adverse events reported in only one study."},"sourceId":"1.1","status":"ok"},{"key":"pmid-25686270","pmid":"25686270","doi":"10.1002/14651858.CD007259.pub2","url":"https://pubmed.ncbi.nlm.nih.gov/25686270/","permalink":"https://alohafungi.com/nauka#pmid-25686270","permalinkEn":"https://alohafungi.com/en/nauka#pmid-25686270","title":"Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors","author":"Klupp N.L. et al.","year":2015,"journal":"Cochrane Database of Systematic Reviews","species":["reishi"],"type":{"pl":"przegląd systematyczny Cochrane z metaanalizą","en":"Cochrane systematic review with meta-analysis"},"n":{"pl":"5 badań, 398 osób","en":"5 studies, 398 people"},"evidenceLevel":"A","preclinical":false,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd zbierał badania z randomizacją nad wpływem Ganoderma lucidum na czynniki ryzyka sercowo-naczyniowego w grupie osób z cukrzycą typu 2. Autorzy wskazali, że tylko 3 z 5 badań dostarczyły dane nadające się do analizy statystycznej.","en":"The review collected randomised studies on the effect of Ganoderma lucidum on cardiovascular risk factors in people with type 2 diabetes. The authors noted that only 3 of 5 studies provided data suitable for statistical analysis."},"sourceId":"1.2","status":"ok"},{"key":"pmid-40510787","pmid":"40510787","doi":"10.1002/fsn3.70423","url":"https://pubmed.ncbi.nlm.nih.gov/40510787/","permalink":"https://alohafungi.com/nauka#pmid-40510787","permalinkEn":"https://alohafungi.com/en/nauka#pmid-40510787","title":"The Nutritional Significance of Ganoderma lucidum on Human Health: A GRADE-Assessed Systematic Review and Meta-Analysis of Clinical Trials","author":"Jafari A. et al.","year":2025,"journal":"Food Science & Nutrition","species":["reishi"],"type":{"pl":"przegląd systematyczny z metaanalizą, ocena GRADE","en":"systematic review with meta-analysis, GRADE assessment"},"n":{"pl":"17 RCT, 971 osób","en":"17 RCTs, 971 people"},"evidenceLevel":"B","preclinical":false,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd zbierał badania kliniczne nad suplementacją Ganoderma lucidum w kontekście wskaźników antropometrycznych, metabolicznych, zapalnych i wątrobowych. Jakość dowodów w ocenie GRADE była bardzo niska dla wszystkich analizowanych punktów końcowych.","en":"The review collected clinical trials on Ganoderma lucidum supplementation regarding anthropometric, metabolic, inflammatory and liver markers. GRADE-assessed evidence quality was very low for all analysed outcomes."},"sourceId":"1.3","status":"ok"},{"key":"pmid-31333449","pmid":"31333449","doi":"10.3389/fphar.2019.00703","url":"https://pubmed.ncbi.nlm.nih.gov/31333449/","permalink":"https://alohafungi.com/nauka#pmid-31333449","permalinkEn":"https://alohafungi.com/en/nauka#pmid-31333449","title":"Coriolus Versicolor and Ganoderma Lucidum Related Natural Products as an Adjunct Therapy for Cancers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","author":"Zhong L. et al.","year":2019,"journal":"Frontiers in Pharmacology","species":["reishi","coriolus"],"type":{"pl":"przegląd systematyczny z metaanalizą RCT","en":"systematic review with meta-analysis of RCTs"},"n":{"pl":"23 badania, 4246 osób","en":"23 studies, 4246 people"},"evidenceLevel":"B","preclinical":false,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd zbierał badania z randomizacją nad preparatami z Coriolus versicolor i Ganoderma lucidum stosowanymi jako terapia dodana u pacjentów onkologicznych. Badania prowadzono niemal wyłącznie w Azji, preparaty i dawki były niejednorodne.","en":"The review collected randomised studies on Coriolus versicolor and Ganoderma lucidum preparations used as adjunct therapy in oncology patients. Studies were conducted almost exclusively in Asia, with heterogeneous preparations and doses."},"sourceId":"1.4","status":"ok"},{"key":"pmid-27511742","pmid":"27511742","doi":"10.1038/srep29540","url":"https://pubmed.ncbi.nlm.nih.gov/27511742/","permalink":"https://alohafungi.com/nauka#pmid-27511742","permalinkEn":"https://alohafungi.com/en/nauka#pmid-27511742","title":"A double-blind, randomised, placebo-controlled trial of Ganoderma lucidum for the treatment of cardiovascular risk factors of metabolic syndrome","author":"Klupp N.L. et al.","year":2016,"journal":"Scientific Reports","species":["reishi"],"type":{"pl":"RCT, podwójnie zaślepione, placebo","en":"RCT, double-blind, placebo-controlled"},"n":{"pl":"84 osoby","en":"84 people"},"evidenceLevel":"C","preclinical":false,"placebo":true,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie sprawdzało wpływ Ganoderma lucidum, osobno oraz w połączeniu z Cordyceps sinensis, na parametry glikemii i pozostałe czynniki ryzyka sercowo-naczyniowego u 84 osób z cukrzycą typu 2 i zespołem metabolicznym. Okres obserwacji ograniczony do 16 tygodni.","en":"The study examined the effect of Ganoderma lucidum, alone and combined with Cordyceps sinensis, on glycaemic parameters and other cardiovascular risk factors in 84 people with type 2 diabetes and metabolic syndrome. Observation period limited to 16 weeks."},"sourceId":"1.5","status":"ok"},{"key":"pmid-18097505","pmid":"18097505","doi":"10.1111/j.1745-7262.2008.00361.x","url":"https://pubmed.ncbi.nlm.nih.gov/18097505/","permalink":"https://alohafungi.com/nauka#pmid-18097505","permalinkEn":"https://alohafungi.com/en/nauka#pmid-18097505","title":"Randomized clinical trial of an ethanol extract of Ganoderma lucidum in men with lower urinary tract symptoms","author":"Noguchi M. et al.","year":2008,"journal":"Asian Journal of Andrology","species":["reishi"],"type":{"pl":"RCT","en":"RCT"},"n":{"pl":"88 mężczyzn powyżej 49 roku życia","en":"88 men over 49 years old"},"evidenceLevel":"C","preclinical":false,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie sprawdzało wpływ ekstraktu etanolowego z Ganoderma lucidum na objawy z dolnych dróg moczowych u 88 mężczyzn powyżej 49 roku życia. Autorzy zarekomendowali dalszą ocenę na dużej próbie i przez dłuższy czas.","en":"The study examined the effect of an ethanol extract of Ganoderma lucidum on lower urinary tract symptoms in 88 men over 49 years old. The authors recommended further evaluation on a larger sample and over a longer period."},"sourceId":"1.6","status":"ok"},{"key":"pmid-38116485","pmid":"38116485","doi":"10.4103/jrms.jrms_175_23","url":"https://pubmed.ncbi.nlm.nih.gov/38116485/","permalink":"https://alohafungi.com/nauka#pmid-38116485","permalinkEn":"https://alohafungi.com/en/nauka#pmid-38116485","title":"Effect of Ganoderma lucidum on serum lipid profiles: A systematic review and meta-analysis on animal studies","author":"Aref M. et al.","year":2023,"journal":"Journal of Research in Medical Sciences","species":["reishi"],"type":{"pl":"metaanaliza badań na zwierzętach","en":"meta-analysis of animal studies"},"n":{"pl":"nie dotyczy, 49 prac","en":"not applicable, 49 papers"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd zbierał badania na zwierzętach nad wpływem Ganoderma lucidum na profil lipidowy surowicy. Zróżnicowanie dawek między badaniami, zakres ograniczony do modeli zwierzęcych.","en":"The review collected animal studies on the effect of Ganoderma lucidum on serum lipid profile. Dose variation between studies, scope limited to animal models."},"sourceId":"1.7","status":"ok"},{"key":"pmid-15857210","pmid":"15857210","doi":"10.1089/jmf.2005.8.53","url":"https://pubmed.ncbi.nlm.nih.gov/15857210/","permalink":"https://alohafungi.com/nauka#pmid-15857210","permalinkEn":"https://alohafungi.com/en/nauka#pmid-15857210","title":"A Randomized, Placebo-Controlled Trial of Ganoderma lucidum for Neurasthenia","author":"Tang W. et al.","year":2005,"journal":"Journal of Medicinal Food","species":["reishi"],"type":{"pl":"RCT, podwójnie zaślepione, placebo","en":"RCT, double-blind, placebo-controlled"},"n":{"pl":"132 osoby (Chiny)","en":"132 people (China)"},"evidenceLevel":"C","preclinical":false,"placebo":true,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie sprawdzało wpływ 8-tygodniowego przyjmowania ekstraktu polisacharydowego z Ganoderma lucidum na wynik skali nasilenia objawów neurastenii u 132 chińskich pacjentów. Ograniczeń nie podano wprost w streszczeniu.","en":"The study examined the effect of 8 weeks of taking a Ganoderma lucidum polysaccharide extract on a neurasthenia symptom severity scale score in 132 Chinese patients. Limitations were not stated explicitly in the abstract."},"sourceId":"1.8","status":"ok"},{"key":"pmid-22207209","pmid":"22207209","doi":"10.1016/j.jep.2011.12.020","url":"https://pubmed.ncbi.nlm.nih.gov/22207209/","permalink":"https://alohafungi.com/nauka#pmid-22207209","permalinkEn":"https://alohafungi.com/en/nauka#pmid-22207209","title":"Extract of Ganoderma lucidum prolongs sleep time in rats","author":"Cui X.Y. et al.","year":2012,"journal":"Journal of Ethnopharmacology","species":["reishi"],"type":{"pl":"badanie zwierzęce (szczury)","en":"animal study (rats)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie na szczurach sprawdzało wpływ 3-dniowego podawania ekstraktu Ganoderma lucidum (80 mg/kg) na całkowity czas snu i sen NREM oraz na poziom TNF-α we krwi i mózgu, z użyciem przeciwciał blokujących TNF-α do sprawdzenia mechanizmu.","en":"The rat study examined the effect of a 3-day Ganoderma lucidum extract administration (80 mg/kg) on total sleep time and NREM sleep, and on TNF-α levels in blood and brain, using TNF-α blocking antibodies to test the mechanism."},"sourceId":"1.9","status":"ok"},{"key":"pmid-17383716","pmid":"17383716","doi":"10.1016/j.pbb.2007.02.015","url":"https://pubmed.ncbi.nlm.nih.gov/17383716/","permalink":"https://alohafungi.com/nauka#pmid-17383716","permalinkEn":"https://alohafungi.com/en/nauka#pmid-17383716","title":"A water-soluble extract from Ganoderma lucidum induces sleep via a GABAergic mechanism","author":"Chu Q.P. et al.","year":2007,"journal":"Pharmacology Biochemistry and Behavior","species":["reishi"],"type":{"pl":"badanie zwierzęce (szczury)","en":"animal study (rats)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie na szczurach sprawdzało wpływ wodnego ekstraktu (80 i 120 mg/kg) na architekturę snu u zdrowych zwierząt oraz na sen indukowany pentobarbitalem, z użyciem flumazenilu do sprawdzenia mechanizmu GABAergicznego.","en":"The rat study examined the effect of an aqueous extract (80 and 120 mg/kg) on sleep architecture in healthy animals and on pentobarbital-induced sleep, using flumazenil to test the GABAergic mechanism."},"sourceId":"1.10","status":"ok"},{"key":"pmid-40077714","pmid":"40077714","doi":"10.3390/nu17050844","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11901880/","permalink":"https://alohafungi.com/nauka#pmid-40077714","permalinkEn":"https://alohafungi.com/en/nauka#pmid-40077714","title":"12-Week Ganoderma lucidum Spore Oil Supplementation and Lipid Profile in Borderline Hypertriglyceridemia","author":"Wang X. et al.","year":2025,"journal":"Nutrients","species":["reishi"],"type":{"pl":"RCT, podwójnie zaślepione, placebo","en":"RCT, double-blind, placebo-controlled"},"n":{"pl":"110 zrandomizowanych (55/grupę w analizie końcowej), 12 tygodni","en":"110 randomised (55/group in final analysis), 12 weeks"},"evidenceLevel":"C","preclinical":false,"placebo":true,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie sprawdzało wpływ 12-tygodniowego przyjmowania oleju z zarodników Ganoderma lucidum (3 g dziennie, ok. 1 g triterpenów) na profil lipidowy oraz bezpieczeństwo nerkowe i wątrobowe u osób z granicznie podwyższonymi triglicerydami. Ograniczenie do populacji z graniczną hipertriglicerydemią i krótki, 12-tygodniowy okres obserwacji.","en":"The study examined the effect of 12 weeks of Ganoderma lucidum spore oil supplementation (3 g daily, approx. 1 g triterpenes) on lipid profile and kidney/liver safety in people with borderline elevated triglycerides. Limited to a population with borderline hypertriglyceridemia and a short 12-week observation period."},"sourceId":"1.11","status":"ok"},{"key":"pmid-34858228","pmid":"34858228","doi":"10.3389/fpsyt.2021.754921","url":"https://pubmed.ncbi.nlm.nih.gov/34858228/","permalink":"https://alohafungi.com/nauka#pmid-34858228","permalinkEn":"https://alohafungi.com/en/nauka#pmid-34858228","title":"Cordyceps militaris jako dodatek do duloksetyny w bezsenności przy depresji","author":"Zhou J. et al.","year":2021,"journal":"Frontiers in Psychiatry","species":["cordyceps"],"type":{"pl":"RCT, podwójnie zaślepione, placebo","en":"RCT, double-blind, placebo-controlled"},"n":{"pl":"59 osób","en":"59 people"},"evidenceLevel":"C","preclinical":false,"placebo":true,"caseReport":false,"subspecies":"militaris","whatWasTested":{"pl":"Badanie sprawdzało Cordyceps militaris jako dodatek do duloksetyny w leczeniu bezsenności towarzyszącej depresji, w grupie 59 osób, metodą RCT z podwójnym zaślepieniem i placebo.","en":"The study examined Cordyceps militaris as an add-on to duloxetine for insomnia associated with depression, in a group of 59 people, using a double-blind, placebo-controlled RCT design."},"sourceId":"4.1","status":"ok"},{"key":"pmid-38580687","pmid":"38580687","doi":"10.1038/s41598-024-58742-z","url":"https://pubmed.ncbi.nlm.nih.gov/38580687/","permalink":"https://alohafungi.com/nauka#pmid-38580687","permalinkEn":"https://alohafungi.com/en/nauka#pmid-38580687","title":"Napój z Cordyceps militaris a odpowiedź immunologiczna zdrowych dorosłych","author":"Ontawong A. et al.","year":2024,"journal":"Scientific Reports","species":["cordyceps"],"type":{"pl":"RCT","en":"RCT"},"n":{"pl":"40 zdrowych dorosłych","en":"40 healthy adults"},"evidenceLevel":"C","preclinical":false,"placebo":null,"caseReport":false,"subspecies":"militaris","whatWasTested":{"pl":"Badanie sprawdzało wpływ napoju z Cordyceps militaris na odpowiedź immunologiczną u 40 zdrowych dorosłych, metodą RCT.","en":"The study examined the effect of a Cordyceps militaris beverage on immune response in 40 healthy adults, using an RCT design."},"sourceId":"4.2","status":"ok"},{"key":"pmid-37727187","pmid":"37727187","doi":"10.7759/cureus.43731","url":"https://pubmed.ncbi.nlm.nih.gov/37727187/","permalink":"https://alohafungi.com/nauka#pmid-37727187","permalinkEn":"https://alohafungi.com/en/nauka#pmid-37727187","title":"Cordyceps militaris w łagodnym/umiarkowanym COVID-19","author":"Dubhashi S. et al.","year":2023,"journal":"Cureus","species":["cordyceps"],"type":{"pl":"RCT, podwójnie zaślepione, placebo","en":"RCT, double-blind, placebo-controlled"},"n":{"pl":"65 włączonych, 58 ocenionych","en":"65 enrolled, 58 evaluated"},"evidenceLevel":"C","preclinical":false,"placebo":true,"caseReport":false,"subspecies":"militaris","whatWasTested":{"pl":"Badanie sprawdzało Cordyceps militaris w łagodnym lub umiarkowanym przebiegu COVID-19, metodą RCT z podwójnym zaślepieniem i placebo, na 65 włączonych osobach (58 ocenionych).","en":"The study examined Cordyceps militaris in mild-to-moderate COVID-19, using a double-blind, placebo-controlled RCT, with 65 people enrolled (58 evaluated)."},"sourceId":"4.3","status":"ok"},{"key":"pmid-41432716","pmid":"41432716","doi":"10.1002/ptr.70144","url":"https://pubmed.ncbi.nlm.nih.gov/41432716/","permalink":"https://alohafungi.com/nauka#pmid-41432716","permalinkEn":"https://alohafungi.com/en/nauka#pmid-41432716","title":"Przegląd in vitro/in vivo/kliniczny Cordyceps militaris","author":"Yang E.-J. et al.","year":2026,"journal":"Phytotherapy Research","species":["cordyceps"],"type":{"pl":"przegląd narracyjny","en":"narrative review"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":"militaris","whatWasTested":{"pl":"Przegląd narracyjny zbierał dane in vitro, in vivo i kliniczne o Cordyceps militaris.","en":"The narrative review collected in vitro, in vivo and clinical data on Cordyceps militaris."},"sourceId":"4.4","status":"ok"},{"key":"pmid-41280379","pmid":"41280379","doi":"10.3389/fnut.2025.1670416","url":"https://pubmed.ncbi.nlm.nih.gov/41280379/","permalink":"https://alohafungi.com/nauka#pmid-41280379","permalinkEn":"https://alohafungi.com/en/nauka#pmid-41280379","title":"Suplementacja grzybami u sportowców (wiele gatunków naraz)","author":"Shu M.-Y. et al.","year":2025,"journal":"Frontiers in Nutrition","species":["cordyceps"],"type":{"pl":"przegląd systematyczny z metaanalizą","en":"systematic review with meta-analysis"},"n":{"pl":"14 RCT, 528 sportowców","en":"14 RCTs, 528 athletes"},"evidenceLevel":"B","preclinical":false,"placebo":null,"caseReport":false,"subspecies":"militaris","whatWasTested":{"pl":"Przegląd systematyczny z metaanalizą zbierał 14 RCT (528 sportowców) nad suplementacją grzybami funkcjonalnymi u sportowców; badanie obejmuje wiele gatunków grzybów naraz, nie tylko Cordyceps militaris.","en":"The systematic review with meta-analysis collected 14 RCTs (528 athletes) on functional mushroom supplementation in athletes; the review covers multiple mushroom species at once, not only Cordyceps militaris."},"sourceId":"4.5","status":"ok"},{"key":"pmid-33312018","pmid":"33312018","doi":"10.1080/12298093.2020.1831135","url":"https://pubmed.ncbi.nlm.nih.gov/33312018/","permalink":"https://alohafungi.com/nauka#pmid-33312018","permalinkEn":"https://alohafungi.com/en/nauka#pmid-33312018","title":"Wydolność u myszy po podaniu Cordyceps militaris","author":"Choi E. et al.","year":2020,"journal":"Mycobiology","species":["cordyceps"],"type":{"pl":"badanie zwierzęce (myszy)","en":"animal study (mice)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":"militaris","whatWasTested":{"pl":"Badanie na myszach sprawdzało wpływ Cordyceps militaris na wydolność fizyczną.","en":"The mouse study examined the effect of Cordyceps militaris on physical performance."},"sourceId":"4.6","status":"ok"},{"key":"pmid-27408987","pmid":"27408987","doi":"10.1080/19390211.2016.1203386","url":"https://pubmed.ncbi.nlm.nih.gov/27408987/","permalink":"https://alohafungi.com/nauka#pmid-27408987","permalinkEn":"https://alohafungi.com/en/nauka#pmid-27408987","title":"Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation","author":"Hirsch K.R. et al.","year":2017,"journal":"Journal of Dietary Supplements","species":["cordyceps"],"type":{"pl":"RCT, podwójnie zaślepione, placebo (mieszanka grzybowa, nie izolowany gatunek)","en":"RCT, double-blind, placebo-controlled (mushroom blend, not an isolated species)"},"n":{"pl":"28 (faza ostra), 10 (faza przewlekła)","en":"28 (acute phase), 10 (chronic phase)"},"evidenceLevel":"C","preclinical":false,"placebo":true,"caseReport":false,"subspecies":"militaris","whatWasTested":{"pl":"Sprawdzano wpływ mieszanki grzybowej z C. militaris (4 g/dobę) na VO2max, czas do wyczerpania, próg wentylacyjny i moc w teście na cykloergometrze, w schemacie 1- i 3-tygodniowym u trenujących dorosłych. Ograniczenia: n=10 w fazie przewlekłej, preparat wieloskładnikowy nieizolujący gatunku.","en":"The study examined the effect of a mushroom blend containing C. militaris (4 g/day) on VO2max, time to exhaustion, ventilatory threshold and power in a cycle ergometer test, using 1-week and 3-week protocols in trained adults. Limitations: n=10 in the chronic phase, a multi-ingredient preparation not isolating the species."},"sourceId":"4.7","status":"ok"},{"key":"pmid-41829950","pmid":"41829950","doi":"10.3390/nu18050781","url":"https://www.mdpi.com/2072-6643/18/5/781","permalink":"https://alohafungi.com/nauka#pmid-41829950","permalinkEn":"https://alohafungi.com/en/nauka#pmid-41829950","title":"Current Evidence of Ergogenic and Post-Exercise Recovery Effects of Dietary Supplementation with Cordyceps militaris in Humans: A Narrative Review","author":"Jędrejko M. et al.","year":2026,"journal":"Nutrients","species":["cordyceps"],"type":{"pl":"przegląd narracyjny badań na ludziach","en":"narrative review of human studies"},"n":{"pl":"5 badań, 321 uczestników 16-35 lat","en":"5 studies, 321 participants aged 16-35"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":"militaris","whatWasTested":{"pl":"Przegląd zbierał 5 badań interwencyjnych 2017-2024 nad efektami ergogenicznymi i regeneracją powysiłkową przy suplementacji u ludzi. Małe próby, heterogeniczność uczestników i protokołów, niepełne raportowanie randomizacji, brak rejestracji większości badań.","en":"The narrative review collected 5 intervention studies (2017-2024) on ergogenic effects and post-exercise recovery with supplementation in humans. Small samples, heterogeneous participants and protocols, incomplete randomisation reporting, most studies not registered."},"sourceId":"4.8","status":"ok"},{"key":"doi-10-1007-s13205-013-0121-9","pmid":null,"doi":"10.1007/s13205-013-0121-9","url":"https://doi.org/10.1007/s13205-013-0121-9","permalink":"https://alohafungi.com/nauka#doi-10-1007-s13205-013-0121-9","permalinkEn":"https://alohafungi.com/en/nauka#doi-10-1007-s13205-013-0121-9","title":"Pharmacological and therapeutic potential of Cordyceps with special reference to Cordycepin","author":"Tuli H.S. et al.","year":2014,"journal":"3 Biotech","species":["cordyceps"],"type":{"pl":"przegląd narracyjny","en":"narrative review"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":"militaris","whatWasTested":{"pl":"Przegląd omawiał potencjał farmakologiczny rodzaju Cordyceps ze szczególnym uwzględnieniem kordycepiny na podstawie danych in vitro/in vivo.","en":"The review discussed the pharmacological potential of the genus Cordyceps, with particular focus on cordycepin, based on in vitro/in vivo data."},"sourceId":"4.9","status":"unknown"},{"key":"pmid-29775778","pmid":"29775778","doi":"10.1016/j.fitote.2018.05.010","url":"https://doi.org/10.1016/j.fitote.2018.05.010","permalink":"https://alohafungi.com/nauka#pmid-29775778","permalinkEn":"https://alohafungi.com/en/nauka#pmid-29775778","title":"The genus Cordyceps: An extensive review of its traditional uses, phytochemistry and pharmacology","author":"Olatunji O.J. et al.","year":2018,"journal":"Fitoterapia","species":["cordyceps"],"type":{"pl":"przegląd narracyjny (cały rodzaj Cordyceps)","en":"narrative review (whole genus Cordyceps)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":"militaris","whatWasTested":{"pl":"Przegląd zbierał tradycyjne zastosowania, fitochemię i farmakologię całego rodzaju Cordyceps bez rozdzielenia gatunków.","en":"The review collected traditional uses, phytochemistry and pharmacology of the entire genus Cordyceps without separating species."},"sourceId":"4.10","status":"ok"},{"key":"doi-10-26502-jbb-2642-91280035","pmid":null,"doi":"10.26502/jbb.2642-91280035","url":"https://doi.org/10.26502/jbb.2642-91280035","permalink":"https://alohafungi.com/nauka#doi-10-26502-jbb-2642-91280035","permalinkEn":"https://alohafungi.com/en/nauka#doi-10-26502-jbb-2642-91280035","title":"Przegląd mechanistyczny, spekulatywny wątek COVID","author":"Du J. et al.","year":2021,"journal":"Journal of Biotechnology and Biomedicine","species":["cordyceps"],"type":{"pl":"przegląd narracyjny","en":"narrative review"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":"militaris","whatWasTested":{"pl":"Praca omawiała mechanizmy interakcji kordycepiny z receptorami adenozynowymi i hipotetycznie łączyła to z ochroną mózgu i COVID-19. Czysto teoretyczna, bez własnych danych.","en":"The paper discussed mechanisms of cordycepin interaction with adenosine receptors and hypothetically linked this to brain protection and COVID-19. Purely theoretical, with no original data."},"sourceId":"4.11","status":"unknown"},{"key":"pmid-17386115","pmid":"17386115","doi":"10.1186/1749-8546-2-3","url":"https://pubmed.ncbi.nlm.nih.gov/17386115/","permalink":"https://alohafungi.com/nauka#pmid-17386115","permalinkEn":"https://alohafungi.com/en/nauka#pmid-17386115","title":"Przegląd narracyjny wielu ziół TCM, Cordyceps jako jeden z przykładów","author":"Ko K.M., Leung H.Y.","year":2007,"journal":"Chinese Medicine","species":["cordyceps"],"type":{"pl":"przegląd narracyjny","en":"narrative review"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":"militaris","whatWasTested":{"pl":"Przegląd omawiał zioła tonizujące TCM (Cordyceps jako jeden z kilku) w kontekście ATP, antyoksydacji i immunomodulacji. Nie izoluje Cordyceps.","en":"The review discussed TCM tonic herbs (Cordyceps as one of several) in the context of ATP, antioxidation and immunomodulation. Does not isolate Cordyceps."},"sourceId":"4.12","status":"ok"},{"key":"pmid-20804368","pmid":"20804368","doi":"10.1089/acm.2009.0226","url":"https://pubmed.ncbi.nlm.nih.gov/20804368/","permalink":"https://alohafungi.com/nauka#pmid-20804368","permalinkEn":"https://alohafungi.com/en/nauka#pmid-20804368","title":"Cs-4 a wydolność osób starszych","author":"Chen S. et al.","year":2010,"journal":"Journal of Alternative and Complementary Medicine","species":["cordyceps"],"type":{"pl":"RCT pilotażowe","en":"pilot RCT"},"n":{"pl":"20 włączonych, 15 ukończyło","en":"20 enrolled, 15 completed"},"evidenceLevel":"D","preclinical":false,"placebo":null,"caseReport":false,"subspecies":"sinensis","whatWasTested":{"pl":"Pilotażowe badanie randomizowane sprawdzało wpływ preparatu Cs-4 (fermentowany produkt z Cordyceps sinensis) na wydolność fizyczną osób starszych, 20 włączonych, 15 ukończyło.","en":"The pilot randomised study examined the effect of the Cs-4 preparation (a fermented Cordyceps sinensis product) on physical performance in older adults, 20 enrolled, 15 completed."},"sourceId":"4b.1","status":"ok"},{"key":"pmid-15118196","pmid":"15118196","doi":"10.1123/ijsnem.14.2.236","url":"https://pubmed.ncbi.nlm.nih.gov/15118196/","permalink":"https://alohafungi.com/nauka#pmid-15118196","permalinkEn":"https://alohafungi.com/en/nauka#pmid-15118196","title":"CordyMax Cs-4 u kolarzy","author":"Parcell A.C. et al.","year":2004,"journal":"International Journal of Sport Nutrition and Exercise Metabolism","species":["cordyceps"],"type":{"pl":"RCT, podwójnie zaślepione","en":"RCT, double-blind"},"n":{"pl":"22 kolarzy","en":"22 cyclists"},"evidenceLevel":"C","preclinical":false,"placebo":null,"caseReport":false,"subspecies":"sinensis","whatWasTested":{"pl":"Badanie RCT z podwójnym zaślepieniem sprawdzało wpływ preparatu CordyMax Cs-4 (Cordyceps sinensis) na wydolność u 22 kolarzy.","en":"The double-blind RCT examined the effect of the CordyMax Cs-4 preparation (Cordyceps sinensis) on performance in 22 cyclists."},"sourceId":"4b.2","status":"ok"},{"key":"pmid-31073318","pmid":"31073318","doi":"10.1155/2019/4903671","url":"https://pubmed.ncbi.nlm.nih.gov/31073318/","permalink":"https://alohafungi.com/nauka#pmid-31073318","permalinkEn":"https://alohafungi.com/en/nauka#pmid-31073318","title":"Cordyceps sinensis w stabilnej POChP","author":"Yu X. et al.","year":2019,"journal":"Evidence-Based Complementary and Alternative Medicine","species":["cordyceps"],"type":{"pl":"przegląd systematyczny z metaanalizą","en":"systematic review with meta-analysis"},"n":{"pl":"14 RCT, 1192 osoby","en":"14 RCTs, 1192 people"},"evidenceLevel":"B","preclinical":false,"placebo":null,"caseReport":false,"subspecies":"sinensis","whatWasTested":{"pl":"Przegląd systematyczny z metaanalizą zbierał 14 RCT (1192 osoby) nad Cordyceps sinensis w stabilnej przewlekłej obturacyjnej chorobie płuc (POChP).","en":"The systematic review with meta-analysis collected 14 RCTs (1192 people) on Cordyceps sinensis in stable chronic obstructive pulmonary disease (COPD)."},"sourceId":"4b.3","status":"ok"},{"key":"pmid-39839641","pmid":"39839641","doi":"10.3389/fmed.2024.1477569","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11747039/","permalink":"https://alohafungi.com/nauka#pmid-39839641","permalinkEn":"https://alohafungi.com/en/nauka#pmid-39839641","title":"Efficacy of traditional Chinese medicine Cordyceps sinensis as an adjunctive treatment in patients with renal dysfunction: a systematic-review and meta-analysis","author":"Wu F. et al.","year":2025,"journal":"Frontiers in Medicine","species":["cordyceps"],"type":{"pl":"przegląd systematyczny z metaanalizą RCT","en":"systematic review with meta-analysis of RCTs"},"n":{"pl":"15 RCT, 1310 osób","en":"15 RCTs, 1310 people"},"evidenceLevel":"B","preclinical":false,"placebo":null,"caseReport":false,"subspecies":"sinensis","whatWasTested":{"pl":"Metaanaliza zbierała RCT nad doustnym Cordyceps sinensis jako terapią wspomagającą u pacjentów z zaburzeniami czynności nerek (kreatynina, czas skąpomoczu, osmolalność moczu). Małe próby, krótkie obserwacje, przewaga badań z Chin.","en":"The meta-analysis collected RCTs on oral Cordyceps sinensis as adjunct therapy in patients with renal dysfunction (creatinine, oliguria duration, urine osmolality). Small samples, short observation periods, predominance of studies from China."},"sourceId":"4b.4","status":"ok"},{"key":"pmid-21549819","pmid":"21549819","doi":"10.1016/j.jep.2011.04.040","url":"https://pubmed.ncbi.nlm.nih.gov/21549819/","permalink":"https://alohafungi.com/nauka#pmid-21549819","permalinkEn":"https://alohafungi.com/en/nauka#pmid-21549819","title":"Cordyceps sinensis promotes exercise endurance capacity of rats","author":"Kumar R. et al.","year":2011,"journal":"Journal of Ethnopharmacology","species":["cordyceps"],"type":{"pl":"badanie zwierzęce (szczury)","en":"animal study (rats)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":"sinensis","whatWasTested":{"pl":"Badanie na szczurach sprawdzało wydolność wysiłkową i regulatory metaboliczne mięśni szkieletowych po podaniu Cordyceps sinensis.","en":"The rat study examined exercise endurance capacity and skeletal muscle metabolic regulators after Cordyceps sinensis administration."},"sourceId":"4b.5","status":"ok"},{"key":"pmid-10755473","pmid":"10755473","doi":"10.1016/s0024-3205(00)00445-8","url":"https://pubmed.ncbi.nlm.nih.gov/10755473/","permalink":"https://alohafungi.com/nauka#pmid-10755473","permalinkEn":"https://alohafungi.com/en/nauka#pmid-10755473","title":"Protein constituent contributes to the hypotensive and vasorelaxant activities of Cordyceps sinensis","author":"Chiou W.F. et al.","year":2000,"journal":"Life Sciences","species":["cordyceps"],"type":{"pl":"zwierzęce (szczury) + in vitro (aorta)","en":"animal (rats) + in vitro (aorta)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":"sinensis","whatWasTested":{"pl":"Badanie na znieczulonych szczurach i izolowanych pierścieniach aorty sprawdzało wpływ frakcji białkowej Cordyceps sinensis na ciśnienie tętnicze (podanie dożylne) i relaksację naczyniową. Model zwierzęcy, podanie dożylne, nie przekłada się na suplement doustny.","en":"The study in anaesthetised rats and isolated aortic rings examined the effect of a Cordyceps sinensis protein fraction on arterial pressure (intravenous administration) and vascular relaxation. Animal model, intravenous administration, does not translate to an oral supplement."},"sourceId":"4b.6","status":"ok"},{"key":"pmid-38116085","pmid":"38116085","doi":"10.3389/fphar.2023.1273786","url":"https://pubmed.ncbi.nlm.nih.gov/38116085/","permalink":"https://alohafungi.com/nauka#pmid-38116085","permalinkEn":"https://alohafungi.com/en/nauka#pmid-38116085","title":"Chaga mushroom: a super-fungus with countless facets and untapped potential","author":"Fordjour E. et al.","year":2023,"journal":"Frontiers in Pharmacology","species":["chaga"],"type":{"pl":"przegląd narracyjny","en":"narrative review"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd narracyjny omawiał właściwości i potencjalne zastosowania chagi opisywane w literaturze.","en":"The narrative review discussed the properties and potential applications of chaga described in the literature."},"sourceId":"3.1","status":"ok"},{"key":"pmid-38813471","pmid":"38813471","doi":"10.1080/21501203.2023.2260408","url":"https://pubmed.ncbi.nlm.nih.gov/38813471/","permalink":"https://alohafungi.com/nauka#pmid-38813471","permalinkEn":"https://alohafungi.com/en/nauka#pmid-38813471","title":"Therapeutic properties of Inonotus obliquus (Chaga mushroom): A review","author":"Tee Yon Ern P. et al.","year":2023,"journal":"Mycology","species":["chaga"],"type":{"pl":"przegląd narracyjny","en":"narrative review"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd narracyjny omawiał właściwości Inonotus obliquus opisywane w literaturze.","en":"The narrative review discussed the properties of Inonotus obliquus described in the literature."},"sourceId":"3.2","status":"ok"},{"key":"pmid-39170453","pmid":"39170453","doi":"10.1016/j.heliyon.2024.e35638","url":"https://pubmed.ncbi.nlm.nih.gov/39170453/","permalink":"https://alohafungi.com/nauka#pmid-39170453","permalinkEn":"https://alohafungi.com/en/nauka#pmid-39170453","title":"A brief overview of the medicinal and nutraceutical importance of Inonotus obliquus (chaga) mushrooms","author":"Camilleri E. et al.","year":2024,"journal":"Heliyon","species":["chaga"],"type":{"pl":"przegląd narracyjny","en":"narrative review"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Krótki przegląd narracyjny omawiał znaczenie medyczne i nutraceutyczne chagi.","en":"The brief narrative review discussed the medicinal and nutraceutical significance of chaga."},"sourceId":"3.3","status":"ok"},{"key":"pmid-25576897","pmid":"25576897","doi":"10.1016/j.jep.2014.12.069","url":"https://pubmed.ncbi.nlm.nih.gov/25576897/","permalink":"https://alohafungi.com/nauka#pmid-25576897","permalinkEn":"https://alohafungi.com/en/nauka#pmid-25576897","title":"Chemical characterization and biological activity of Chaga","author":"Glamočlija J. et al.","year":2015,"journal":"Journal of Ethnopharmacology","species":["chaga"],"type":{"pl":"in vitro + chemia","en":"in vitro + chemistry"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie in vitro sprawdzało skład chemiczny i aktywność biologiczną ekstraktów z chagi.","en":"The in vitro study examined the chemical composition and biological activity of chaga extracts."},"sourceId":"3.4","status":"ok"},{"key":"pmid-29484963","pmid":"29484963","doi":"10.1177/1534735418757912","url":"https://pubmed.ncbi.nlm.nih.gov/29484963/","permalink":"https://alohafungi.com/nauka#pmid-29484963","permalinkEn":"https://alohafungi.com/en/nauka#pmid-29484963","title":"Chaga, a Future Potential Medicinal Fungus in Oncology?","author":"Géry A. et al.","year":2018,"journal":"Integrative Cancer Therapies","species":["chaga"],"type":{"pl":"in vitro","en":"in vitro"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie in vitro sprawdzało aktywność przeciwnowotworową ekstraktów z chagi na liniach komórkowych.","en":"The in vitro study examined the anticancer activity of chaga extracts on cell lines."},"sourceId":"3.5","status":"ok"},{"key":"pmid-27441282","pmid":"27441282","doi":"10.1016/j.heliyon.2016.e00111","url":"https://pubmed.ncbi.nlm.nih.gov/27441282/","permalink":"https://alohafungi.com/nauka#pmid-27441282","permalinkEn":"https://alohafungi.com/en/nauka#pmid-27441282","title":"Continuous intake of the Chaga mushroom aqueous extract suppresses cancer progression","author":"Arata S. et al.","year":2016,"journal":"Heliyon","species":["chaga"],"type":{"pl":"badanie zwierzęce (myszy)","en":"animal study (mice)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie na myszach sprawdzało wpływ ciągłego podawania wodnego ekstraktu z chagi na progresję nowotworu.","en":"The mouse study examined the effect of continuous administration of an aqueous chaga extract on cancer progression."},"sourceId":"3.6","status":"ok"},{"key":"pmid-28954386","pmid":"28954386","doi":"10.1016/j.biopha.2017.09.104","url":"https://pubmed.ncbi.nlm.nih.gov/28954386/","permalink":"https://alohafungi.com/nauka#pmid-28954386","permalinkEn":"https://alohafungi.com/en/nauka#pmid-28954386","title":"Anti-diabetic effects of Inonotus obliquus polysaccharides in streptozotocin-induced type 2 diabetic mice","author":"Wang J. et al.","year":2017,"journal":"Biomedicine & Pharmacotherapy","species":["chaga"],"type":{"pl":"badanie zwierzęce (myszy)","en":"animal study (mice)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie w modelu myszy z cukrzycą typu 2 wywołaną streptozotocyną sprawdzało działanie przeciwcukrzycowe polisacharydów z Inonotus obliquus.","en":"The study in streptozotocin-induced type 2 diabetic mice examined the anti-diabetic effect of Inonotus obliquus polysaccharides."},"sourceId":"3.7","status":"ok"},{"key":"pmid-35451393","pmid":"35451393","doi":"10.1097/MD.0000000000028997","url":"https://pubmed.ncbi.nlm.nih.gov/35451393/","permalink":"https://alohafungi.com/nauka#pmid-35451393","permalinkEn":"https://alohafungi.com/en/nauka#pmid-35451393","title":"Chaga mushroom-induced oxalate nephropathy that clinically manifested as nephrotic syndrome","author":"Kwon O. et al.","year":2022,"journal":"Medicine (Baltimore)","species":["chaga"],"type":{"pl":"opis przypadku, bezpieczeństwo","en":"case report, safety"},"n":{"pl":"1 pacjent, mężczyzna 69 lat","en":"1 patient, 69-year-old man"},"evidenceLevel":"D","preclinical":false,"placebo":null,"caseReport":true,"subspecies":null,"whatWasTested":{"pl":"Opis przypadku dokumentował nefropatię szczawianową po spożyciu chagi, która klinicznie objawiła się zespołem nerczycowym u 69-letniego mężczyzny. Pojedynczy przypadek, dane z bezpieczeństwa.","en":"The case report documented oxalate nephropathy after chaga intake, clinically manifesting as nephrotic syndrome in a 69-year-old man. Single case, safety data."},"sourceId":"3.8","status":"ok"},{"key":"pmid-32419395","pmid":"32419395","doi":"10.3346/jkms.2020.35.e122","url":"https://pubmed.ncbi.nlm.nih.gov/32419395/","permalink":"https://alohafungi.com/nauka#pmid-32419395","permalinkEn":"https://alohafungi.com/en/nauka#pmid-32419395","title":"Development of End Stage Renal Disease after Long-Term Ingestion of Chaga Mushroom","author":"Lee S. et al.","year":2020,"journal":"Journal of Korean Medical Science","species":["chaga"],"type":{"pl":"opis przypadku, bezpieczeństwo","en":"case report, safety"},"n":{"pl":"1 pacjent, mężczyzna 49 lat","en":"1 patient, 49-year-old man"},"evidenceLevel":"D","preclinical":false,"placebo":null,"caseReport":true,"subspecies":null,"whatWasTested":{"pl":"Opis przypadku dokumentował rozwój schyłkowej niewydolności nerek po długotrwałym spożywaniu chagi u 49-letniego mężczyzny. Pojedynczy przypadek, dane z bezpieczeństwa.","en":"The case report documented the development of end-stage renal disease after long-term chaga ingestion in a 49-year-old man. Single case, safety data."},"sourceId":"3.9","status":"ok"},{"key":"pmid-29421057","pmid":"29421057","doi":"10.1016/j.carbpol.2017.12.041","url":"https://pubmed.ncbi.nlm.nih.gov/29421057/","permalink":"https://alohafungi.com/nauka#pmid-29421057","permalinkEn":"https://alohafungi.com/en/nauka#pmid-29421057","title":"Structural characterization of bioactive heteropolysaccharides from the fruiting bodies of Chaga","author":"Wold C.W. et al.","year":2018,"journal":"Carbohydrate Polymers","species":["chaga"],"type":{"pl":"chemia + in vitro","en":"chemistry + in vitro"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie sprawdzało budowę chemiczną frakcji polisacharydowych z wnętrza i zewnętrza owocnika (metody strukturalne) oraz ich wpływ na produkcję tlenku azotu w liniach mysich makrofagów i komórek dendrytycznych in vitro.","en":"The study examined the chemical structure of polysaccharide fractions from the inner and outer parts of the fruiting body (structural methods) and their effect on nitric oxide production in mouse macrophage and dendritic cell lines in vitro."},"sourceId":"3.10","status":"ok"},{"key":"pmid-23149251","pmid":"23149251","doi":"10.5414/CN107655","url":"https://pubmed.ncbi.nlm.nih.gov/23149251/","permalink":"https://alohafungi.com/nauka#pmid-23149251","permalinkEn":"https://alohafungi.com/en/nauka#pmid-23149251","title":"Chronic interstitial nephritis and oxalate crystal deposition after chaga mushroom intake","author":"Kikuchi Y. et al.","year":2014,"journal":"Clinical Nephrology","species":["chaga"],"type":{"pl":"opis przypadku, bezpieczeństwo (chronologicznie pierwszy z trzech)","en":"case report, safety (chronologically the first of three)"},"n":{"pl":"1 pacjentka, kobieta 72 lata","en":"1 patient, 72-year-old woman"},"evidenceLevel":"D","preclinical":false,"placebo":null,"caseReport":true,"subspecies":null,"whatWasTested":{"pl":"Opis przypadku dokumentował powiązanie 6-miesięcznego spożywania proszku z chagi (4-5 łyżeczek dziennie) przez 72-letnią pacjentkę po hepatektomii z powodu raka wątroby z pogorszeniem funkcji nerek wymagającym hemodializy; biopsja wykazała rozlany zanik cewek, włóknienie śródmiąższowe i kryształy szczawianu. Chronologicznie pierwszy z trzech opisanych przypadków (2014, przed Lee 2020 i Kwon 2022).","en":"The case report documented a link between 6 months of chaga powder intake (4-5 teaspoons daily) by a 72-year-old woman after hepatectomy for liver cancer and worsening kidney function requiring haemodialysis; biopsy showed diffuse tubular atrophy, interstitial fibrosis and oxalate crystals. Chronologically the first of three reported cases (2014, before Lee 2020 and Kwon 2022)."},"sourceId":"3.11","status":"ok"},{"key":"doi-10-1155-2022-8251344","pmid":null,"doi":"10.1155/2022/8251344","url":"https://doi.org/10.1155/2022/8251344","permalink":"https://alohafungi.com/nauka#doi-10-1155-2022-8251344","permalinkEn":"https://alohafungi.com/en/nauka#doi-10-1155-2022-8251344","title":"In vitro study on macrophages and nitric oxide","author":"Shen D. et al.","year":2022,"journal":"Evidence-Based Complementary and Alternative Medicine","species":["chaga"],"type":{"pl":"in vitro","en":"in vitro"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie sprawdzało wpływ ekstraktu na poziom tlenku azotu i markery zapalne w spoczynkowych makrofagach M0 oraz aktywowanych LPS makrofagach M1 in vitro, przy różnych stężeniach.","en":"The study examined the effect of the extract on nitric oxide levels and inflammatory markers in resting M0 macrophages and LPS-activated M1 macrophages in vitro, at various concentrations."},"sourceId":"3.12","status":"unknown"},{"key":"pmid-36445793","pmid":"36445793","doi":"10.1002/14651858.CD012053.pub2","url":"https://pubmed.ncbi.nlm.nih.gov/36445793/","permalink":"https://alohafungi.com/nauka#pmid-36445793","permalinkEn":"https://alohafungi.com/en/nauka#pmid-36445793","title":"Oral polysaccharopeptide for the prevention or amelioration of chemotherapy or radiotherapy-related side effects in patients with colorectal cancer","author":"Pilkington K. et al.","year":2022,"journal":"Cochrane Database of Systematic Reviews","species":["coriolus"],"type":{"pl":"przegląd Cochrane z metaanalizą (PSK, lek)","en":"Cochrane review with meta-analysis (PSK, drug)"},"n":{"pl":"7 RCT, 1569 osób","en":"7 RCTs, 1569 people"},"evidenceLevel":"A","preclinical":false,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd systematyczny Cochrane z metaanalizą zbierał 7 RCT (1569 osób) nad wpływem PSK (lek, nie suplement) na działania niepożądane chemioterapii/radioterapii w raku jelita grubego.","en":"The Cochrane systematic review with meta-analysis collected 7 RCTs (1569 people) on the effect of PSK (a pharmaceutical drug, not a supplement) on adverse effects of chemotherapy/radiotherapy in colorectal cancer."},"sourceId":"5.1","status":"ok"},{"key":"pmid-17106715","pmid":"17106715","doi":"10.1007/s00262-006-0248-1","url":"https://pubmed.ncbi.nlm.nih.gov/17106715/","permalink":"https://alohafungi.com/nauka#pmid-17106715","permalinkEn":"https://alohafungi.com/en/nauka#pmid-17106715","title":"Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curative resections of gastric cancer","author":"Oba K. et al.","year":2006,"journal":"Cancer Immunology, Immunotherapy","species":["coriolus"],"type":{"pl":"metaanaliza RCT (PSK, lek)","en":"meta-analysis of RCTs (PSK, drug)"},"n":{"pl":"8 RCT, 8009 pacjentów","en":"8 RCTs, 8009 patients"},"evidenceLevel":"A","preclinical":false,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Metaanaliza RCT zbierała 8 badań (8009 pacjentów) nad PSK (lek) jako terapią wspomagającą w raku żołądka.","en":"The meta-analysis of RCTs collected 8 studies (8009 patients) on PSK (a drug) as adjunct therapy in gastric cancer."},"sourceId":"5.2","status":"ok"},{"key":"pmid-29179503","pmid":"29179503","doi":"10.18632/oncotarget.19059","url":"https://pubmed.ncbi.nlm.nih.gov/29179503/","permalink":"https://alohafungi.com/nauka#pmid-29179503","permalinkEn":"https://alohafungi.com/en/nauka#pmid-29179503","title":"PSK Induces Autophagy through the PI3K/Akt/mTOR Pathway and Suppresses Cell Growth: Meta-Analysis in Gastrointestinal Cancers","author":"Ma Y. et al.","year":2017,"journal":"Oncotarget","species":["coriolus"],"type":{"pl":"metaanaliza sieciowa (PSK, lek)","en":"network meta-analysis (PSK, drug)"},"n":{"pl":"23 badania, 10 684 pacjentów","en":"23 studies, 10,684 patients"},"evidenceLevel":"B","preclinical":false,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Metaanaliza sieciowa zbierała 23 badania (10 684 pacjentów) nad PSK (lek) w nowotworach przewodu pokarmowego.","en":"The network meta-analysis collected 23 studies (10,684 patients) on PSK (a drug) in gastrointestinal cancers."},"sourceId":"5.3","status":"ok"},{"key":"pmid-12814145","pmid":"12814145","doi":"10.1053/rmed.2003.1490","url":"https://pubmed.ncbi.nlm.nih.gov/12814145/","permalink":"https://alohafungi.com/nauka#pmid-12814145","permalinkEn":"https://alohafungi.com/en/nauka#pmid-12814145","title":"Coriolus versicolor polysaccharide peptide slows progression of advanced non-small cell lung cancer","author":"Tsang K.W. et al.","year":2003,"journal":"Respiratory Medicine","species":["coriolus"],"type":{"pl":"RCT pilotażowe, placebo (PSP, lek)","en":"pilot RCT, placebo-controlled (PSP, drug)"},"n":{"pl":"68 osób","en":"68 people"},"evidenceLevel":"C","preclinical":false,"placebo":true,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Pilotażowe RCT z placebo sprawdzało PSP (lek) w niedrobnokomórkowym raku płuca (NDRP) u 68 osób.","en":"The pilot placebo-controlled RCT examined PSP (a drug) in non-small cell lung cancer (NSCLC) in 68 people."},"sourceId":"5.5","status":"ok"},{"key":"pmid-22701186","pmid":"22701186","doi":"10.5402/2012/251632","url":"https://pubmed.ncbi.nlm.nih.gov/22701186/","permalink":"https://alohafungi.com/nauka#pmid-22701186","permalinkEn":"https://alohafungi.com/en/nauka#pmid-22701186","title":"Phase 1 clinical trial of Trametes versicolor in women with breast cancer","author":"Torkelson C.J. et al.","year":2012,"journal":"ISRN Oncology","species":["coriolus"],"type":{"pl":"faza I, eskalacja dawki (cały ekstrakt, nie lek)","en":"phase I, dose escalation (whole extract, not a drug)"},"n":{"pl":"11 zrekrutowanych, 9 ukończyło","en":"11 recruited, 9 completed"},"evidenceLevel":"D","preclinical":false,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie fazy I z eskalacją dawki sprawdzało bezpieczeństwo i tolerancję pełnego ekstraktu z Trametes versicolor (nie oczyszczonego leku PSK/PSP) u kobiet po radioterapii z powodu raka piersi. 11 zrekrutowanych, 9 ukończyło.","en":"The phase I dose-escalation study examined the safety and tolerability of a whole Trametes versicolor extract (not the purified PSK/PSP drug) in women after radiotherapy for breast cancer. 11 recruited, 9 completed."},"sourceId":"5.6","status":"ok"},{"key":"pmid-25006989","pmid":"25006989","doi":"10.4161/gmic.29558","url":"https://pubmed.ncbi.nlm.nih.gov/25006989/","permalink":"https://alohafungi.com/nauka#pmid-25006989","permalinkEn":"https://alohafungi.com/en/nauka#pmid-25006989","title":"Effect of polysaccharopeptide from Trametes versicolor and amoxicillin on the gut microbiome of healthy volunteers","author":"Pallav K. et al.","year":2014,"journal":"Gut Microbes","species":["coriolus"],"type":{"pl":"RCT (PSP, lek)","en":"RCT (PSP, drug)"},"n":{"pl":"24 zrekrutowanych, 22 ukończyło","en":"24 recruited, 22 completed"},"evidenceLevel":"C","preclinical":false,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"RCT sprawdzało wpływ PSP (lek) w połączeniu z amoksycyliną na mikrobiom jelitowy zdrowych osób. 24 zrekrutowanych, 22 ukończyło.","en":"The RCT examined the effect of PSP (a drug) combined with amoxicillin on the gut microbiome of healthy people. 24 recruited, 22 completed."},"sourceId":"5.7","status":"ok"},{"key":"pmid-12792790","pmid":"12792790","doi":"","url":"https://pubmed.ncbi.nlm.nih.gov/12792790/","permalink":"https://alohafungi.com/nauka#pmid-12792790","permalinkEn":"https://alohafungi.com/en/nauka#pmid-12792790","title":"Randomized controlled trial of postoperative adjuvant chemoimmunotherapy with PSK","author":"Koda K. et al.","year":2003,"journal":"International Journal of Oncology","species":["coriolus"],"type":{"pl":"RCT (PSK, lek)","en":"RCT (PSK, drug)"},"n":{"pl":"558 osób","en":"558 people"},"evidenceLevel":"C","preclinical":false,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"RCT sprawdzało PSK (lek) dodany do chemioterapii pooperacyjnej u 558 osób.","en":"The RCT examined PSK (a drug) added to postoperative chemotherapy in 558 people."},"sourceId":"5.8","status":"ok"},{"key":"pmid-23435630","pmid":"23435630","doi":"10.1007/s11130-013-0342-4","url":"https://pubmed.ncbi.nlm.nih.gov/23435630/","permalink":"https://alohafungi.com/nauka#pmid-23435630","permalinkEn":"https://alohafungi.com/en/nauka#pmid-23435630","title":"Trametes versicolor extract modifies human fecal microbiota composition in vitro","author":"Yu Z.T. et al.","year":2013,"journal":"Plant Foods for Human Nutrition","species":["coriolus"],"type":{"pl":"in vitro (fermentacja kału ludzkiego, PSP)","en":"in vitro (human faecal fermentation, PSP)"},"n":{"pl":"liczba dawców nieokreślona","en":"number of donors not specified"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie in vitro sprawdzało fermentację PSP przez ludzką mikrobiotę kałową hodowaną poza organizmem (skład bakterii, pH) w porównaniu z fruktooligosacharydami.","en":"The in vitro study examined the fermentation of PSP by human faecal microbiota cultured outside the body (bacterial composition, pH) compared with fructooligosaccharides."},"sourceId":"5.9","status":"ok"},{"key":"pmid-28932226","pmid":"28932226","doi":"10.3389/fimmu.2017.01087","url":"https://pubmed.ncbi.nlm.nih.gov/28932226/","permalink":"https://alohafungi.com/nauka#pmid-28932226","permalinkEn":"https://alohafungi.com/en/nauka#pmid-28932226","title":"Immunomodulatory Properties of Coriolus versicolor: The Role of Polysaccharopeptide","author":"Saleh M.H. et al.","year":2017,"journal":"Frontiers in Immunology","species":["coriolus"],"type":{"pl":"przegląd narracyjny (PSP)","en":"narrative review (PSP)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd narracyjny omawiał mechanizmy immunomodulacyjne PSP (cytokiny, mikrośrodowisko guza) w kontekście terapii adjuwantowej w Azji.","en":"The narrative review discussed the immunomodulatory mechanisms of PSP (cytokines, tumour microenvironment) in the context of adjuvant therapy in Asia."},"sourceId":"5.10","status":"ok"},{"key":"pmid-22159900","pmid":"22159900","doi":"10.3892/ijo.2011.1292","url":"https://pubmed.ncbi.nlm.nih.gov/22159900/","permalink":"https://alohafungi.com/nauka#pmid-22159900","permalinkEn":"https://alohafungi.com/en/nauka#pmid-22159900","title":"Polysaccharide-K augments docetaxel-induced tumor suppression","author":"Wenner C.A. et al.","year":2012,"journal":"International Journal of Oncology","species":["coriolus"],"type":{"pl":"zwierzęce (myszy, PSK)","en":"animal (mice, PSK)"},"n":{"pl":"nieokreślone","en":"not specified"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie na myszach sprawdzało PSK (lek) w połączeniu z docetakselem (wielkość guza, infiltracja limfocytów, aktywność komórek NK).","en":"The mouse study examined PSK (a drug) combined with docetaxel (tumour size, lymphocyte infiltration, NK cell activity)."},"sourceId":"5.11","status":"ok"},{"key":"pmid-19087769","pmid":"19087769","doi":"","url":"https://pubmed.ncbi.nlm.nih.gov/19087769/","permalink":"https://alohafungi.com/nauka#pmid-19087769","permalinkEn":"https://alohafungi.com/en/nauka#pmid-19087769","title":"Trametes versicolor mushroom immune therapy in breast cancer","author":"Standish L.J. et al.","year":2008,"journal":"Journal of the Society for Integrative Oncology","species":["coriolus"],"type":{"pl":"przegląd narracyjny (PSK)","en":"narrative review (PSK)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd syntetyzował azjatyckie RCT nad PSK (lek: rak żołądka, jelita grubego, przełyku, piersi) i mechanizmy immunologiczne. Brak danych o działaniu całego ekstraktu w odróżnieniu od PSK.","en":"The review synthesised Asian RCTs on PSK (a drug: gastric, colorectal, oesophageal, breast cancer) and immunological mechanisms. No data on the effect of the whole extract as distinct from PSK."},"sourceId":"5.12","status":"ok"},{"key":"pmid-22185453","pmid":"22185453","doi":"10.2174/187221312798889310","url":"https://pubmed.ncbi.nlm.nih.gov/22185453/","permalink":"https://alohafungi.com/nauka#pmid-22185453","permalinkEn":"https://alohafungi.com/en/nauka#pmid-22185453","title":"Efficacy of Yun Zhi (Coriolus versicolor) on survival in cancer patients: systematic review and meta-analysis","author":"Wong E.L.Y. et al.","year":2012,"journal":"Recent Patents on Inflammation & Allergy Drug Discovery","species":["coriolus"],"type":{"pl":"przegląd systematyczny z metaanalizą (PSK, lek)","en":"systematic review with meta-analysis (PSK, drug)"},"n":{"pl":"13 badań klinicznych","en":"13 clinical studies"},"evidenceLevel":"B","preclinical":false,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Metaanaliza sprawdzała wpływ preparatów PSK (lek) dodanych do standardowego leczenia na przeżycie pacjentów onkologicznych, na podstawie 13 badań klinicznych.","en":"The meta-analysis examined the effect of PSK (a drug) preparations added to standard treatment on survival of cancer patients, based on 13 clinical studies."},"sourceId":"5.13","status":"ok"},{"key":"pmid-32466253","pmid":"32466253","doi":"10.3390/biomedicines8050135","url":"https://pubmed.ncbi.nlm.nih.gov/32466253/","permalink":"https://alohafungi.com/nauka#pmid-32466253","permalinkEn":"https://alohafungi.com/en/nauka#pmid-32466253","title":"Trametes versicolor Polysaccharides in Cancer Therapy: Targets and Efficacy","author":"Habtemariam S.","year":2020,"journal":"Biomedicines","species":["coriolus"],"type":{"pl":"przegląd narracyjny (PSP i PSK)","en":"narrative review (PSP and PSK)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd syntetyzował dowody in vitro, in vivo i kliniczne dla komercyjnych preparatów PSP i PSK jako terapii wspomagającej.","en":"The review synthesised in vitro, in vivo and clinical evidence for commercial PSP and PSK preparations as adjunct therapy."},"sourceId":"5.14","status":"ok"},{"key":"pmid-14499133","pmid":"14499133","doi":"10.1016/s0734-9750(03)00002-8","url":"https://pubmed.ncbi.nlm.nih.gov/14499133/","permalink":"https://alohafungi.com/nauka#pmid-14499133","permalinkEn":"https://alohafungi.com/en/nauka#pmid-14499133","title":"Polysaccharopeptides of Coriolus versicolor: physiological activity, uses, and production","author":"Cui J., Chisti Y.","year":2003,"journal":"Biotechnology Advances","species":["coriolus"],"type":{"pl":"przegląd narracyjny, bioprocesowy (PSP)","en":"narrative review, bioprocess-focused (PSP)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd narracyjny skupiony na produkcji biotechnologicznej PSP, z krótkim omówieniem aktywności biologicznej.","en":"The narrative review focused on the biotechnological production of PSP, with a brief discussion of biological activity."},"sourceId":"5.15","status":"ok"},{"key":"pmid-30169542","pmid":"30169542","doi":"10.1371/journal.pone.0203064","url":"https://pubmed.ncbi.nlm.nih.gov/30169542/","permalink":"https://alohafungi.com/nauka#pmid-30169542","permalinkEn":"https://alohafungi.com/en/nauka#pmid-30169542","title":"Antioxidative, antifungal, cytotoxic and antineurodegenerative activity of selected Trametes species from Serbia","author":"Knežević A. et al.","year":2018,"journal":"PLoS One","species":["coriolus"],"type":{"pl":"in vitro, 3 gatunki Trametes","en":"in vitro, 3 Trametes species"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie in vitro sprawdzało aktywność antyoksydacyjną, przeciwgrzybiczą, cytotoksyczność i hamowanie acetylocholinoesterazy/tyrozynazy dla ekstraktów trzech gatunków Trametes z Serbii.","en":"The in vitro study examined antioxidant, antifungal, cytotoxic activity and acetylcholinesterase/tyrosinase inhibition for extracts of three Trametes species from Serbia."},"sourceId":"5.16","status":"ok"},{"key":"pmid-29146352","pmid":"29146352","doi":"10.1016/j.foodchem.2017.09.149","url":"https://pubmed.ncbi.nlm.nih.gov/29146352/","permalink":"https://alohafungi.com/nauka#pmid-29146352","permalinkEn":"https://alohafungi.com/en/nauka#pmid-29146352","title":"Anti-inflammatory properties of edible mushrooms: A review","author":"Muszyńska B. et al.","year":2018,"journal":"Food Chemistry","species":["coriolus","shiitake","polyporus","pornatka"],"type":{"pl":"przegląd ogólny (nie dotyczy konkretnie Coriolus)","en":"general review (not specifically about Coriolus)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd ogólny właściwości przeciwzapalnych grzybów jadalnych; nie dotyczy konkretnie Coriolus, to źródło wspólne wykorzystywane w wielu hubach gatunków.","en":"General review of the anti-inflammatory properties of edible mushrooms; does not specifically concern Coriolus, a source shared across multiple species hubs."},"sourceId":"5.17","status":"ok"},{"key":"pmid-41620671","pmid":"41620671","doi":"10.1186/s12865-026-00809-9","url":"https://pubmed.ncbi.nlm.nih.gov/41620671/","permalink":"https://alohafungi.com/nauka#pmid-41620671","permalinkEn":"https://alohafungi.com/en/nauka#pmid-41620671","title":"Polypore mushroom mycelia as an adjunct to COVID-19 vaccination: a randomized clinical trial","author":"Saxe G. et al.","year":2026,"journal":"BMC Immunology","species":["coriolus"],"type":{"pl":"RCT, podwójnie zaślepione, placebo (preparat łączony FoTv, nie sam Coriolus)","en":"RCT, double-blind, placebo-controlled (combined FoTv preparation, not Coriolus alone)"},"n":{"pl":"90 (52 FoTv, 38 placebo)","en":"90 (52 FoTv, 38 placebo)"},"evidenceLevel":"C","preclinical":false,"placebo":true,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"RCT sprawdzało bezpieczeństwo i wykonalność podania preparatu grzybniowego FoTv (Fomitopsis officinalis + Trametes versicolor) jako uzupełnienia szczepienia przeciw COVID-19, z obserwacją do 6 miesięcy. Preparat łączony dwóch gatunków, wyników nie wolno przypisywać samemu wrośniakowi.","en":"The RCT examined the safety and feasibility of administering the FoTv mycelium preparation (Fomitopsis officinalis + Trametes versicolor) as an adjunct to COVID-19 vaccination, with observation up to 6 months. A combined preparation of two species; results cannot be attributed to Trametes versicolor alone."},"sourceId":"5.18","status":"ok"},{"key":"doi-10-3390-cimb47100808","pmid":null,"doi":"10.3390/cimb47100808","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12564590/","permalink":"https://alohafungi.com/nauka#doi-10-3390-cimb47100808","permalinkEn":"https://alohafungi.com/en/nauka#doi-10-3390-cimb47100808","title":"Exploring the Anticancer Potential of Coriolus versicolor in Breast Cancer: A Review","author":"Ziaja-Sołtys M., Jaszek M.","year":2025,"journal":"Current Issues in Molecular Biology","species":["coriolus"],"type":{"pl":"przegląd (bez pełnego protokołu PRISMA), głównie przedkliniczny","en":"review (no full PRISMA protocol), mostly preclinical"},"n":{"pl":"11 badań, w tym 1 faza I (= 5.6)","en":"11 studies, including 1 phase I study (= 5.6)"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd zebrał 11 badań z lat 2010-2025 nad Coriolus versicolor w raku piersi, głównie linie komórkowe i myszy oraz jedno badanie fazy I. Potrzeba większych badań kontrolowanych placebo.","en":"The review collected 11 studies (2010-2025) on Coriolus versicolor in breast cancer, mostly cell lines and mice, plus one phase I study. Larger placebo-controlled studies are needed."},"sourceId":"5.19","status":"unknown"},{"key":"pmid-42055721","pmid":"42055721","doi":"10.3177/jnsv.72.163","url":"https://pubmed.ncbi.nlm.nih.gov/42055721/","permalink":"https://alohafungi.com/nauka#pmid-42055721","permalinkEn":"https://alohafungi.com/en/nauka#pmid-42055721","title":"Effect of Grifola frondosa on cognitive function in healthy older adults","author":"Jogi E.M. et al.","year":2026,"journal":"Journal of Nutritional Science and Vitaminology","species":["maitake"],"type":{"pl":"RCT, podwójnie zaślepione, placebo","en":"RCT, double-blind, placebo-controlled"},"n":{"pl":"47 zdrowych osób 60+","en":"47 healthy people aged 60+"},"evidenceLevel":"C","preclinical":false,"placebo":true,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"RCT z podwójnym zaślepieniem i placebo sprawdzało wpływ Grifola frondosa na funkcje poznawcze u 47 zdrowych osób w wieku 60+.","en":"The double-blind, placebo-controlled RCT examined the effect of Grifola frondosa on cognitive function in 47 healthy people aged 60+."},"sourceId":"6.1","status":"ok"},{"key":"pmid-19253021","pmid":"19253021","doi":"10.1007/s00432-009-0562-z","url":"https://pubmed.ncbi.nlm.nih.gov/19253021/","permalink":"https://alohafungi.com/nauka#pmid-19253021","permalinkEn":"https://alohafungi.com/en/nauka#pmid-19253021","title":"A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients","author":"Deng G. et al.","year":2009,"journal":"Journal of Cancer Research and Clinical Oncology","species":["maitake"],"type":{"pl":"faza I/II, eskalacja dawki","en":"phase I/II, dose escalation"},"n":{"pl":"34 kobiety","en":"34 women"},"evidenceLevel":"D","preclinical":false,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie fazy I/II z eskalacją dawki sprawdzało bezpieczeństwo i efekty immunologiczne ekstraktu z Grifola frondosa u 34 kobiet po leczeniu raka piersi.","en":"The phase I/II dose-escalation study examined the safety and immunological effects of a Grifola frondosa extract in 34 women after breast cancer treatment."},"sourceId":"6.2","status":"ok"},{"key":"pmid-25351719","pmid":"25351719","doi":"10.1007/s00262-014-1628-6","url":"https://pubmed.ncbi.nlm.nih.gov/25351719/","permalink":"https://alohafungi.com/nauka#pmid-25351719","permalinkEn":"https://alohafungi.com/en/nauka#pmid-25351719","title":"Maitake mushroom extract in myelodysplastic syndromes","author":"Wesa K.M. et al.","year":2015,"journal":"Cancer Immunology, Immunotherapy","species":["maitake"],"type":{"pl":"faza II","en":"phase II"},"n":{"pl":"21 włączonych, 18 ocenionych","en":"21 enrolled, 18 evaluated"},"evidenceLevel":"D","preclinical":false,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie fazy II sprawdzało ekstrakt z Grifola frondosa w zespole mielodysplastycznym (MDS) u 21 włączonych osób (18 ocenionych).","en":"The phase II study examined a Grifola frondosa extract in myelodysplastic syndrome (MDS) in 21 enrolled people (18 evaluated)."},"sourceId":"6.3","status":"ok"},{"key":"pmid-21034160","pmid":"21034160","doi":"10.1089/acm.2009.0696","url":"https://pubmed.ncbi.nlm.nih.gov/21034160/","permalink":"https://alohafungi.com/nauka#pmid-21034160","permalinkEn":"https://alohafungi.com/en/nauka#pmid-21034160","title":"Effectiveness of Maitake extract on ovulation induction in women with polycystic ovary syndrome","author":"Chen J.-T. et al.","year":2010,"journal":"Journal of Alternative and Complementary Medicine","species":["maitake"],"type":{"pl":"randomizowane, otwarte, bez zaślepienia","en":"randomised, open-label, no blinding"},"n":{"pl":"80 pacjentek","en":"80 patients"},"evidenceLevel":"D","preclinical":false,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie randomizowane, otwarte (bez zaślepienia) sprawdzało ekstrakt z Grifola frondosa w zespole policystycznych jajników (PCOS) u 80 pacjentek.","en":"The randomised, open-label study (no blinding) examined a Grifola frondosa extract in polycystic ovary syndrome (PCOS) in 80 patients."},"sourceId":"6.4","status":"ok"},{"key":"pmid-19476741","pmid":"19476741","doi":"","url":"https://pubmed.ncbi.nlm.nih.gov/19476741/","permalink":"https://alohafungi.com/nauka#pmid-19476741","permalinkEn":"https://alohafungi.com/en/nauka#pmid-19476741","title":"Maitake mushroom: Natural Standard evidence-based systematic review","author":"Ulbricht C. et al.","year":2009,"journal":"Journal of the Society for Integrative Oncology","species":["maitake"],"type":{"pl":"przegląd systematyczny","en":"systematic review"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"B","preclinical":false,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd systematyczny (metoda Natural Standard) zbierał dostępne dane o zastosowaniach i bezpieczeństwie Grifola frondosa.","en":"The systematic review (Natural Standard methodology) collected available data on the uses and safety of Grifola frondosa."},"sourceId":"6.5","status":"ok"},{"key":"pmid-14977447","pmid":"14977447","doi":"10.1089/109662003772519949","url":"https://pubmed.ncbi.nlm.nih.gov/14977447/","permalink":"https://alohafungi.com/nauka#pmid-14977447","permalinkEn":"https://alohafungi.com/en/nauka#pmid-14977447","title":"Can maitake MD-fraction aid cancer patients?","author":"Kodama N. et al.","year":2003,"journal":"Journal of Medicinal Food","species":["maitake"],"type":{"pl":"obserwacyjne, bez kontroli","en":"observational, uncontrolled"},"n":{"pl":"10 pacjentów","en":"10 patients"},"evidenceLevel":"D","preclinical":false,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie obserwacyjne bez grupy kontrolnej sprawdzało wpływ frakcji D z Grifola frondosa na aktywność komórek NK u 10 pacjentów onkologicznych.","en":"The uncontrolled observational study examined the effect of the D-fraction from Grifola frondosa on NK cell activity in 10 oncology patients."},"sourceId":"6.6","status":"ok"},{"key":"pmid-34271115","pmid":"34271115","doi":"10.1016/j.jep.2021.114395","url":"https://pubmed.ncbi.nlm.nih.gov/34271115/","permalink":"https://alohafungi.com/nauka#pmid-34271115","permalinkEn":"https://alohafungi.com/en/nauka#pmid-34271115","title":"Preclinical meta-analysis of Grifola frondosa animal studies","author":"Zhao F. et al.","year":2021,"journal":"Journal of Ethnopharmacology","species":["maitake"],"type":{"pl":"metaanaliza zwierzęca","en":"animal meta-analysis"},"n":{"pl":"24 badania","en":"24 studies"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Metaanaliza przedkliniczna zbierała 24 badania na zwierzętach nad Grifola frondosa.","en":"The preclinical meta-analysis collected 24 animal studies on Grifola frondosa."},"sourceId":"6.7","status":"ok"},{"key":"pmid-37193332","pmid":"37193332","doi":"10.1007/s13205-023-03617-9","url":"https://pubmed.ncbi.nlm.nih.gov/37193332/","permalink":"https://alohafungi.com/nauka#pmid-37193332","permalinkEn":"https://alohafungi.com/en/nauka#pmid-37193332","title":"Long-term dosing safety study of Grifola frondosa in mice","author":"Liu J. et al.","year":2023,"journal":"3 Biotech","species":["maitake"],"type":{"pl":"badanie zwierzęce","en":"animal study"},"n":{"pl":"20 myszy","en":"20 mice"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie na 20 myszach sprawdzało bezpieczeństwo długoterminowego podawania różnych dawek Grifola frondosa.","en":"The study in 20 mice examined the safety of long-term administration of various Grifola frondosa doses."},"sourceId":"6.8","status":"ok"},{"key":"pmid-11903406","pmid":"11903406","doi":"10.1046/j.1464-5491.2001.00532-5.x","url":"https://pubmed.ncbi.nlm.nih.gov/11903406/","permalink":"https://alohafungi.com/nauka#pmid-11903406","permalinkEn":"https://alohafungi.com/en/nauka#pmid-11903406","title":"A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients","author":"Konno S. et al.","year":2001,"journal":"Diabetic Medicine","species":["maitake"],"type":{"pl":"pilotaż, list badawczy, bez kontroli","en":"pilot, research letter, uncontrolled"},"n":{"pl":"6 pacjentów","en":"6 patients"},"evidenceLevel":"D","preclinical":false,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Krótki list badawczy opisywał obserwację glikemii u sześciorga pacjentów z cukrzycą typu 2 przyjmujących ekstrakt. Bardzo mała próba, brak kontroli.","en":"A brief research letter described glycaemia observations in six type 2 diabetes patients taking the extract. Very small sample, no control group."},"sourceId":"6.9","status":"ok"},{"key":"pmid-23569395","pmid":"23569395","doi":"10.2147/IJGM.S41891","url":"https://pubmed.ncbi.nlm.nih.gov/23569395/","permalink":"https://alohafungi.com/nauka#pmid-23569395","permalinkEn":"https://alohafungi.com/en/nauka#pmid-23569395","title":"Possible hypoglycemic action of SX-fraction targeting insulin signal transduction pathway","author":"Konno S. et al.","year":2013,"journal":"International Journal of General Medicine","species":["maitake"],"type":{"pl":"mechanistyczne in vitro (komórki L6)","en":"mechanistic in vitro (L6 cells)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Praca sprawdzała mechanizm działania frakcji SX na szlak sygnalizacji insulinowej w komórkach mięśniowych L6, z odwołaniem do wcześniejszych obserwacji klinicznych autora.","en":"The study examined the mechanism of action of the SX-fraction on the insulin signalling pathway in L6 muscle cells, referencing the author's earlier clinical observations."},"sourceId":"6.10","status":"ok"},{"key":"pmid-33384765","pmid":"33384765","doi":"10.4239/wjd.v11.i12.572","url":"https://pubmed.ncbi.nlm.nih.gov/33384765/","permalink":"https://alohafungi.com/nauka#pmid-33384765","permalinkEn":"https://alohafungi.com/en/nauka#pmid-33384765","title":"SX-fraction: Promise for novel treatment of type 2 diabetes","author":"Konno S.","year":2020,"journal":"World Journal of Diabetes","species":["maitake"],"type":{"pl":"przegląd narracyjny autora frakcji","en":"narrative review by the fraction's author"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd narracyjny podsumowywał dane o frakcji SX w cukrzycy typu 2; autor jest jednocześnie badaczem pierwotnym frakcji.","en":"A narrative review summarised data on the SX-fraction in type 2 diabetes; the author is also the fraction's original researcher."},"sourceId":"6.11","status":"ok"},{"key":"pmid-7820117","pmid":"7820117","doi":"10.1248/bpb.17.1106","url":"https://pubmed.ncbi.nlm.nih.gov/7820117/","permalink":"https://alohafungi.com/nauka#pmid-7820117","permalinkEn":"https://alohafungi.com/en/nauka#pmid-7820117","title":"Anti-diabetic activity present in the fruit body of Grifola frondosa (Maitake). I.","author":"Kubo K., Aoki H., Nanba H.","year":1994,"journal":"Biological & Pharmaceutical Bulletin","species":["maitake"],"type":{"pl":"badanie zwierzęce (N i dawka niezweryfikowane)","en":"animal study (N and dose not verified)"},"n":{"pl":"nieustalone w tym zwiadzie","en":"not established in this literature review"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Najstarsza praca w zestawieniu, badanie na zwierzętach nad aktywnością przeciwcukrzycową ekstraktu z owocnika (pierwszy opis tzw. frakcji X). Liczba zwierząt i dawka nie zostały zweryfikowane w tym zwiadzie.","en":"The oldest paper in this set, an animal study on the anti-diabetic activity of the fruiting-body extract (first description of the so-called X-fraction). Animal number and dose were not verified in this literature review."},"sourceId":"6.12","status":"ok"},{"key":"pmid-33466429","pmid":"33466429","doi":"10.3390/foods10010095","url":"https://pubmed.ncbi.nlm.nih.gov/33466429/","permalink":"https://alohafungi.com/nauka#pmid-33466429","permalinkEn":"https://alohafungi.com/en/nauka#pmid-33466429","title":"Bioactive Ingredients and Medicinal Values of Grifola frondosa (Maitake)","author":"Wu J.-Y., Siu K.-C., Geng P.","year":2021,"journal":"Foods","species":["maitake"],"type":{"pl":"przegląd narracyjny","en":"narrative review"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd zbierał dane o związkach bioaktywnych (polisacharydy, beta-glukany, białka, sterole, fenole) i ich działaniach opisanych w literaturze.","en":"The review collected data on bioactive compounds (polysaccharides, beta-glucans, proteins, sterols, phenols) and their effects described in the literature."},"sourceId":"6.13","status":"ok"},{"key":"pmid-38439104","pmid":"38439104","doi":"10.1186/s40795-024-00842-0","url":"https://pubmed.ncbi.nlm.nih.gov/38439104/","permalink":"https://alohafungi.com/nauka#pmid-38439104","permalinkEn":"https://alohafungi.com/en/nauka#pmid-38439104","title":"Tremella fuciformis beverage improves glycated hemoglobin A1c and waist circumference in overweight/obese prediabetic subjects","author":"Gitsomboon S. et al.","year":2024,"journal":"BMC Nutrition","species":["tremella"],"type":{"pl":"RCT, podwójnie zaślepione, placebo","en":"RCT, double-blind, placebo-controlled"},"n":{"pl":"56 osób","en":"56 people"},"evidenceLevel":"C","preclinical":false,"placebo":true,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Sprawdzano 12-tygodniowe picie napoju z Tremellą wobec placebo, mierząc HbA1c oraz obwód talii u dorosłych z nadwagą/otyłością i stanem przedcukrzycowym. Jednoośrodkowe, mała próba, autorzy wskazują potrzebę większych RCT.","en":"The 12-week trial examined a Tremella beverage versus placebo, measuring HbA1c and waist circumference in overweight/obese adults with prediabetes. Single-centre, small sample, the authors note the need for larger RCTs."},"sourceId":"7.1","status":"ok"},{"key":"pmid-29319408","pmid":"29319408","doi":"10.1089/jmf.2017.4063","url":"https://pubmed.ncbi.nlm.nih.gov/29319408/","permalink":"https://alohafungi.com/nauka#pmid-29319408","permalinkEn":"https://alohafungi.com/en/nauka#pmid-29319408","title":"Efficacy and Safety of Tremella fuciformis in Individuals with Subjective Cognitive Impairment","author":"Ban S. et al.","year":2018,"journal":"Journal of Medicinal Food","species":["tremella"],"type":{"pl":"RCT, podwójnie zaślepione, placebo, 3 ramiona","en":"RCT, double-blind, placebo-controlled, 3 arms"},"n":{"pl":"75 osób (30/30/15)","en":"75 people (30/30/15)"},"evidenceLevel":"C","preclinical":false,"placebo":true,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Sprawdzano 8 tygodni kapsułek 600 mg lub 1200 mg dziennie wobec placebo u osób z subiektywnym pogorszeniem funkcji poznawczych: bezpieczeństwo, kwestionariusz skarg pamięciowych, testy pamięci i funkcji wykonawczych oraz objętość istoty szarej (MRI). Mała grupa placebo (15 osób), krótki czas.","en":"The trial examined 8 weeks of 600 mg or 1200 mg daily capsules versus placebo in people with subjective cognitive impairment: safety, memory complaint questionnaire, memory and executive function tests, and grey matter volume (MRI). Small placebo group (15 people), short duration."},"sourceId":"7.2","status":"ok"},{"key":"pmid-31030755","pmid":"31030755","doi":"10.1016/j.ijbiomac.2018.10.117","url":"https://doi.org/10.1016/j.ijbiomac.2018.10.117","permalink":"https://alohafungi.com/nauka#pmid-31030755","permalinkEn":"https://alohafungi.com/en/nauka#pmid-31030755","title":"Structure, bioactivities and applications of the polysaccharides from Tremella fuciformis mushroom: A review","author":"Wu Y.J. et al.","year":2019,"journal":"International Journal of Biological Macromolecules","species":["tremella"],"type":{"pl":"przegląd narracyjny","en":"narrative review"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd narracyjny omawiał budowę chemiczną, bioaktywność i zastosowania polisacharydów z Tremella fuciformis, bez pomiaru efektu u ludzi.","en":"The narrative review discussed the chemical structure, bioactivity and applications of Tremella fuciformis polysaccharides, without measuring effects in humans."},"sourceId":"7.3","status":"ok"},{"key":"pmid-24015063","pmid":"24015063","doi":"10.4489/MYCO.2007.35.1.011","url":"https://doi.org/10.4489/MYCO.2007.35.1.011","permalink":"https://alohafungi.com/nauka#pmid-24015063","permalinkEn":"https://alohafungi.com/en/nauka#pmid-24015063","title":"The Neuroprotective and Neurotrophic Effects of Tremella fuciformis in PC12h cells","author":"Park K.J. et al.","year":2007,"journal":"Mycobiology","species":["tremella"],"type":{"pl":"in vitro (linia PC12h)","en":"in vitro (PC12h cell line)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie in vitro (linia komórkowa PC12h) sprawdzało efekty neuroprotekcyjne i neurotroficzne ekstraktu z Tremella fuciformis.","en":"The in vitro study (PC12h cell line) examined the neuroprotective and neurotrophic effects of a Tremella fuciformis extract."},"sourceId":"7.4","status":"ok"},{"key":"pmid-22185695","pmid":"22185695","doi":"10.1016/j.bbr.2011.11.017","url":"https://doi.org/10.1016/j.bbr.2011.11.017","permalink":"https://alohafungi.com/nauka#pmid-22185695","permalinkEn":"https://alohafungi.com/en/nauka#pmid-22185695","title":"Tremella fuciformis enhances the neurite outgrowth of PC12 cells and restores trimethyltin-induced impairment of memory in rats","author":"Park H.J. et al.","year":2012,"journal":"Behavioural Brain Research","species":["tremella"],"type":{"pl":"in vitro + zwierzęce (szczury)","en":"in vitro + animal (rats)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie łączyło model komórkowy (wzrost włókien nerwowych PC12) z modelem zwierzęcym (przywracanie pamięci upośledzonej trimetylocyną u szczurów) po podaniu Tremella fuciformis.","en":"The study combined a cell model (PC12 neurite outgrowth) with an animal model (restoring trimethyltin-impaired memory in rats) after Tremella fuciformis administration."},"sourceId":"7.5","status":"ok"},{"key":"pmid-33686752","pmid":"33686752","doi":"10.1111/jocd.14051","url":"https://pubmed.ncbi.nlm.nih.gov/33686752/","permalink":"https://alohafungi.com/nauka#pmid-33686752","permalinkEn":"https://alohafungi.com/en/nauka#pmid-33686752","title":"Tremella fuciformis polysaccharides inhibit UVA-induced photodamage of human dermal fibroblast cells","author":"Fu H. et al.","year":2021,"journal":"Journal of Cosmetic Dermatology","species":["tremella"],"type":{"pl":"in vitro (ludzkie fibroblasty skóry)","en":"in vitro (human dermal fibroblasts)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie in vitro na ludzkich fibroblastach skóry sprawdzało, czy polisacharydy z Tremella fuciformis hamują fotouszkodzenia wywołane promieniowaniem UVA.","en":"The in vitro study on human dermal fibroblasts examined whether Tremella fuciformis polysaccharides inhibit UVA-induced photodamage."},"sourceId":"7.6","status":"ok"},{"key":"pmid-28627707","pmid":"28627707","doi":"10.3892/mmr.2017.6754","url":"https://doi.org/10.3892/mmr.2017.6754","permalink":"https://alohafungi.com/nauka#pmid-28627707","permalinkEn":"https://alohafungi.com/en/nauka#pmid-28627707","title":"Tremella fuciformis polysaccharide suppresses hydrogen peroxide-triggered injury of human skin fibroblasts via upregulation of SIRT1","author":"Shen T. et al.","year":2017,"journal":"Molecular Medicine Reports","species":["tremella"],"type":{"pl":"in vitro (fibroblasty)","en":"in vitro (fibroblasts)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie in vitro na ludzkich fibroblastach skóry sprawdzało, czy polisacharyd z Tremella fuciformis ogranicza uszkodzenia wywołane nadtlenkiem wodoru poprzez zwiększenie ekspresji SIRT1.","en":"The in vitro study on human dermal fibroblasts examined whether a Tremella fuciformis polysaccharide reduces hydrogen peroxide-induced damage by upregulating SIRT1."},"sourceId":"7.8","status":"ok"},{"key":"pmid-40282763","pmid":"40282763","doi":"10.3390/foods14081362","url":"https://doi.org/10.3390/foods14081362","permalink":"https://alohafungi.com/nauka#pmid-40282763","permalinkEn":"https://alohafungi.com/en/nauka#pmid-40282763","title":"Non-Animal Hyaluronic Acid from Tremella fuciformis: A New Source with a Structure and Chemical Profile Comparable to Hyaluronic Acid","author":"Galla R. et al.","year":2025,"journal":"Foods","species":["tremella"],"type":{"pl":"analiza chemiczna surowca","en":"chemical analysis of the raw material"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Analiza chemiczna surowca sprawdzała, czy związek z Tremella fuciformis ma strukturę i profil chemiczny porównywalne z kwasem hialuronowym pochodzenia zwierzęcego.","en":"The chemical analysis of the raw material examined whether a compound from Tremella fuciformis has a structure and chemical profile comparable to animal-derived hyaluronic acid."},"sourceId":"7.9","status":"ok"},{"key":"pmid-40077789","pmid":"40077789","doi":"10.3390/nu17050914","url":"https://doi.org/10.3390/nu17050914","permalink":"https://alohafungi.com/nauka#pmid-40077789","permalinkEn":"https://alohafungi.com/en/nauka#pmid-40077789","title":"Anti-Stress Effects of Tremella fuciformis Berk. Enzymatic Extracts: A Preclinical Study","author":"Moon G. et al.","year":2025,"journal":"Nutrients","species":["tremella"],"type":{"pl":"zwierzęce (myszy)","en":"animal (mice)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie przedkliniczne na myszach sprawdzało działanie przeciwstresowe enzymatycznych ekstraktów z Tremella fuciformis.","en":"The preclinical mouse study examined the anti-stress effects of enzymatic Tremella fuciformis extracts."},"sourceId":"7.10","status":"ok"},{"key":"pmid-25866155","pmid":"25866155","doi":"10.1080/07315724.2014.950391","url":"https://pubmed.ncbi.nlm.nih.gov/25866155/","permalink":"https://alohafungi.com/nauka#pmid-25866155","permalinkEn":"https://alohafungi.com/en/nauka#pmid-25866155","title":"Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity","author":"Dai X. et al.","year":2015,"journal":"Journal of the American College of Nutrition","species":["shiitake"],"type":{"pl":"RCT równoległe, 2 dawki, bez placebo","en":"parallel RCT, 2 doses, no placebo"},"n":{"pl":"52 osoby (21-41 lat, zdrowi)","en":"52 people (21-41 years old, healthy)"},"evidenceLevel":"C","preclinical":false,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Sprawdzano 4 tygodnie spożycia 5 g lub 10 g suszonego Shiitake dziennie u zdrowych dorosłych, mierząc ex vivo proliferację i aktywację komórek γδ-T i NK-T, sIgA w ślinie, CRP i profil cytokin. Bez grupy placebo, tylko młoda zdrowa populacja, krótki czas; autorzy sami zaznaczają niedostatek badań interwencyjnych na ludziach.","en":"The trial examined 4 weeks of eating 5 g or 10 g dried Shiitake daily in healthy adults, measuring ex vivo proliferation and activation of γδ-T and NK-T cells, salivary sIgA, CRP and cytokine profile. No placebo group, only a young healthy population, short duration; the authors themselves note the shortage of human intervention studies."},"sourceId":"8.1","status":"ok"},{"key":"pmid-5768289","pmid":"5768289","doi":"10.1038/222687a0","url":"https://doi.org/10.1038/222687a0","permalink":"https://alohafungi.com/nauka#pmid-5768289","permalinkEn":"https://alohafungi.com/en/nauka#pmid-5768289","title":"Inhibition of mouse sarcoma 180 by polysaccharides from Lentinus edodes","author":"Chihara G. et al.","year":1969,"journal":"Nature","species":["shiitake"],"type":{"pl":"zwierzęce, izolowana frakcja polisacharydowa (lentinan)","en":"animal, isolated polysaccharide fraction (lentinan)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie na myszach mierzyło hamowanie mięsaka S-180 przez izolowaną frakcję polisacharydową z Lentinus edodes (praca założycielska leku lentinan, nie suplementu).","en":"The mouse study measured inhibition of sarcoma S-180 by an isolated polysaccharide fraction from Lentinus edodes (the founding paper for the lentinan drug, not a supplement)."},"sourceId":"8.2","status":"ok"},{"key":"pmid-27353254","pmid":"27353254","doi":"10.1038/srep28802","url":"https://doi.org/10.1038/srep28802","permalink":"https://alohafungi.com/nauka#pmid-27353254","permalinkEn":"https://alohafungi.com/en/nauka#pmid-27353254","title":"Anti-tumor effect of β-glucan from Lentinus edodes and the underlying mechanism","author":"Xu H. et al.","year":2016,"journal":"Scientific Reports","species":["shiitake"],"type":{"pl":"in vitro + zwierzęce (guz S-180)","en":"in vitro + animal (S-180 tumour)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie in vitro i na zwierzętach (model guza S-180) sprawdzało przeciwnowotworowe działanie β-glukanu z Lentinus edodes i jego mechanizm.","en":"The in vitro and animal study (S-180 tumour model) examined the anticancer effect of β-glucan from Lentinus edodes and its mechanism."},"sourceId":"8.3","status":"ok"},{"key":"pmid-26548936","pmid":"26548936","doi":"10.4103/0019-509X.168953","url":"https://pubmed.ncbi.nlm.nih.gov/26548936/","permalink":"https://alohafungi.com/nauka#pmid-26548936","permalinkEn":"https://alohafungi.com/en/nauka#pmid-26548936","title":"A meta-analysis of lentinan injection combined with chemotherapy in the treatment of nonsmall cell lung cancer","author":"Wang H., Yin X. et al.","year":2015,"journal":"Indian Journal of Cancer","species":["shiitake"],"type":{"pl":"metaanaliza 12 badań klinicznych (lentinan w iniekcji + chemioterapia, lek)","en":"meta-analysis of 12 clinical studies (injectable lentinan + chemotherapy, drug)"},"n":{"pl":"950 osób (492 lentinan / 458 kontrola)","en":"950 people (492 lentinan / 458 control)"},"evidenceLevel":"B","preclinical":false,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Metaanaliza zbierała 12 badań klinicznych lentinanu dożylnego dodanego do chemioterapii niedrobnokomórkowego raka płuca (skuteczność, toksyczność), dane z 2 baz (PubMed, CNKI). Preparat farmaceutyczny podawany dożylnie, wyraźnie inny od suplementu doustnego z owocnika, analogicznie do PSK/PSP przy Coriolus.","en":"The meta-analysis collected 12 clinical studies of intravenous lentinan added to NSCLC chemotherapy (efficacy, toxicity), data from 2 databases (PubMed, CNKI). An intravenous pharmaceutical preparation, clearly different from an oral fruiting-body supplement, analogous to PSK/PSP for Coriolus."},"sourceId":"8.4","status":"ok"},{"key":"pmid-7643248","pmid":"7643248","doi":"10.1093/jn/125.8.2134","url":"https://doi.org/10.1093/jn/125.8.2134","permalink":"https://alohafungi.com/nauka#pmid-7643248","permalinkEn":"https://alohafungi.com/en/nauka#pmid-7643248","title":"Hypocholesterolemic action of eritadenine is mediated by a modification of hepatic phospholipid metabolism in rats","author":"Sugiyama K. et al.","year":1995,"journal":"Journal of Nutrition","species":["shiitake"],"type":{"pl":"zwierzęce (szczury)","en":"animal (rats)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie na szczurach sprawdzało mechanizm działania obniżającego cholesterol eritadeniny (związku z Shiitake) poprzez zmianę metabolizmu fosfolipidów wątrobowych.","en":"The rat study examined the mechanism by which eritadenine (a Shiitake compound) lowers cholesterol via changes in hepatic phospholipid metabolism."},"sourceId":"8.5","status":"ok"},{"key":"pmid-24255670","pmid":"24255670","doi":"10.3892/etm.2013.1333","url":"https://doi.org/10.3892/etm.2013.1333","permalink":"https://alohafungi.com/nauka#pmid-24255670","permalinkEn":"https://alohafungi.com/en/nauka#pmid-24255670","title":"Lentinus edodes promotes fat removal in hypercholesterolemic mice","author":"Yang H. et al.","year":2013,"journal":"Experimental and Therapeutic Medicine","species":["shiitake"],"type":{"pl":"zwierzęce (myszy)","en":"animal (mice)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie na myszach z hipercholesterolemią sprawdzało wpływ Lentinus edodes na usuwanie tłuszczu.","en":"The study in hypercholesterolemic mice examined the effect of Lentinus edodes on fat removal."},"sourceId":"8.6","status":"ok"},{"key":"pmid-18242970","pmid":"18242970","doi":"10.1016/j.phymed.2007.11.029","url":"https://doi.org/10.1016/j.phymed.2007.11.029","permalink":"https://alohafungi.com/nauka#pmid-18242970","permalinkEn":"https://alohafungi.com/en/nauka#pmid-18242970","title":"In vitro cytostatic and immunomodulatory properties of the medicinal mushroom Lentinula edodes","author":"Israilides C. et al.","year":2008,"journal":"Phytomedicine","species":["shiitake"],"type":{"pl":"in vitro (MCF-7, limfocyty)","en":"in vitro (MCF-7, lymphocytes)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie in vitro (linia komórkowa MCF-7 i limfocyty) sprawdzało właściwości cytostatyczne i immunomodulacyjne Lentinula edodes.","en":"The in vitro study (MCF-7 cell line and lymphocytes) examined the cytostatic and immunomodulatory properties of Lentinula edodes."},"sourceId":"8.7","status":"ok"},{"key":"pmid-20491636","pmid":"20491636","doi":"10.2174/092986710791698495","url":"https://doi.org/10.2174/092986710791698495","permalink":"https://alohafungi.com/nauka#pmid-20491636","permalinkEn":"https://alohafungi.com/en/nauka#pmid-20491636","title":"Lentinus edodes: a macrofungus with pharmacological activities","author":"Bisen P.S. et al.","year":2010,"journal":"Current Medicinal Chemistry","species":["shiitake"],"type":{"pl":"przegląd narracyjny","en":"narrative review"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd narracyjny omawiał farmakologiczne właściwości Lentinus edodes opisywane w literaturze.","en":"The narrative review discussed the pharmacological properties of Lentinus edodes described in the literature."},"sourceId":"8.8","status":"ok"},{"key":"doi-10-1016-j-tifs-2023-03-007","pmid":null,"doi":"10.1016/j.tifs.2023.03.007","url":"https://doi.org/10.1016/j.tifs.2023.03.007","permalink":"https://alohafungi.com/nauka#doi-10-1016-j-tifs-2023-03-007","permalinkEn":"https://alohafungi.com/en/nauka#doi-10-1016-j-tifs-2023-03-007","title":"Therapeutic values and nutraceutical properties of shiitake mushroom (Lentinula edodes): A review","author":"Ahmad I. et al.","year":2023,"journal":"Trends in Food Science & Technology","species":["shiitake"],"type":{"pl":"przegląd narracyjny","en":"narrative review"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd narracyjny omawiał wartości terapeutyczne i nutraceutyczne shiitake opisywane w literaturze.","en":"The narrative review discussed the therapeutic and nutraceutical values of shiitake described in the literature."},"sourceId":"8.9","status":"unknown"},{"key":"pmid-24236998","pmid":"24236998","doi":"10.1080/10408398.2011.587616","url":"https://doi.org/10.1080/10408398.2011.587616","permalink":"https://alohafungi.com/nauka#pmid-24236998","permalinkEn":"https://alohafungi.com/en/nauka#pmid-24236998","title":"Polysaccharides in Lentinus edodes: isolation, structure, immunomodulating activity and future prospective","author":"Xu X. et al.","year":2014,"journal":"Critical Reviews in Food Science and Nutrition","species":["shiitake"],"type":{"pl":"przegląd narracyjny","en":"narrative review"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd narracyjny omawiał izolację, budowę i aktywność immunomodulacyjną polisacharydów z Lentinus edodes.","en":"The narrative review discussed the isolation, structure and immunomodulatory activity of Lentinus edodes polysaccharides."},"sourceId":"8.10","status":"ok"},{"key":"pmid-14499107","pmid":"14499107","doi":"10.1016/S1074-7613(03)00233-4","url":"https://doi.org/10.1016/S1074-7613(03)00233-4","permalink":"https://alohafungi.com/nauka#pmid-14499107","permalinkEn":"https://alohafungi.com/en/nauka#pmid-14499107","title":"Fungal β-glucans and mammalian immunity","author":"Brown G.D., Gordon S.","year":2003,"journal":"Immunity","species":["shiitake","polyporus","pornatka"],"type":{"pl":"przegląd narracyjny o beta-glukanach ogólnie (nie dotyczy konkretnie Shiitake)","en":"narrative review of beta-glucans in general (not specifically about Shiitake)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd narracyjny omawiał beta-glukany grzybowe i odporność ssaków ogólnie; nie dotyczy konkretnie Shiitake, to źródło wspólne wykorzystywane w wielu hubach gatunków.","en":"The narrative review discussed fungal beta-glucans and mammalian immunity in general; does not specifically concern Shiitake, a source shared across multiple species hubs."},"sourceId":"8.11","status":"ok"},{"key":"pmid-33543932","pmid":"33543932","doi":"10.1021/acs.jafc.0c05934","url":"https://doi.org/10.1021/acs.jafc.0c05934","permalink":"https://alohafungi.com/nauka#pmid-33543932","permalinkEn":"https://alohafungi.com/en/nauka#pmid-33543932","title":"Review on Auricularia auricula-judae as a Functional Food","author":"Liu E. et al.","year":2021,"journal":"Journal of Agricultural and Food Chemistry","species":["auricularia"],"type":{"pl":"przegląd narracyjny","en":"narrative review"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd narracyjny omawiał Auricularia auricula-judae jako żywność funkcjonalną.","en":"The narrative review discussed Auricularia auricula-judae as a functional food."},"sourceId":"9.1","status":"ok"},{"key":"pmid-26349516","pmid":"26349516","doi":"","url":"https://pubmed.ncbi.nlm.nih.gov/26349516/","permalink":"https://alohafungi.com/nauka#pmid-26349516","permalinkEn":"https://alohafungi.com/en/nauka#pmid-26349516","title":"Extraction, Antimicrobial, and Antioxidant Activities of Crude Polysaccharides from the Wood Ear Medicinal Mushroom","author":"Cai M. et al.","year":2015,"journal":"International Journal of Medicinal Mushrooms","species":["auricularia"],"type":{"pl":"in vitro","en":"in vitro"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie in vitro sprawdzało ekstrakcję oraz aktywność przeciwdrobnoustrojową i antyoksydacyjną surowych polisacharydów z uszaka.","en":"The in vitro study examined the extraction, antimicrobial and antioxidant activity of crude polysaccharides from wood ear mushroom."},"sourceId":"9.2","status":"ok"},{"key":"pmid-19298211","pmid":"19298211","doi":"10.1089/jmf.2007.0568","url":"https://doi.org/10.1089/jmf.2007.0568","permalink":"https://alohafungi.com/nauka#pmid-19298211","permalinkEn":"https://alohafungi.com/en/nauka#pmid-19298211","title":"Antioxidant capacity of fresh and processed fruit bodies and mycelium of Auricularia auricula-judae","author":"Kho Y.S. et al.","year":2009,"journal":"Journal of Medicinal Food","species":["auricularia"],"type":{"pl":"in vitro","en":"in vitro"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie in vitro sprawdzało zdolność antyoksydacyjną świeżych i przetworzonych owocników oraz grzybni uszaka.","en":"The in vitro study examined the antioxidant capacity of fresh and processed fruiting bodies and mycelium of wood ear."},"sourceId":"9.3","status":"ok"},{"key":"pmid-14967412","pmid":"14967412","doi":"10.1016/j.thromres.2003.10.022","url":"https://doi.org/10.1016/j.thromres.2003.10.022","permalink":"https://alohafungi.com/nauka#pmid-14967412","permalinkEn":"https://alohafungi.com/en/nauka#pmid-14967412","title":"The nontoxic mushroom Auricularia auricula contains a polysaccharide with anticoagulant activity mediated by antithrombin","author":"Yoon S.J. et al.","year":2003,"journal":"Thrombosis Research","species":["auricularia"],"type":{"pl":"in vitro","en":"in vitro"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie in vitro sprawdzało aktywność przeciwzakrzepową polisacharydu z Auricularia auricula, zależną od antytrombiny.","en":"The in vitro study examined the antithrombin-mediated anticoagulant activity of a polysaccharide from Auricularia auricula."},"sourceId":"9.4","status":"ok"},{"key":"pmid-32041370","pmid":"32041370","doi":"10.3390/molecules25030710","url":"https://doi.org/10.3390/molecules25030710","permalink":"https://alohafungi.com/nauka#pmid-32041370","permalinkEn":"https://alohafungi.com/en/nauka#pmid-32041370","title":"Extraction Optimization, Structural Characterization, and Anticoagulant Activity of Acidic Polysaccharides from Auricularia auricula","author":"Bian C. et al.","year":2020,"journal":"Molecules","species":["auricularia"],"type":{"pl":"in vitro","en":"in vitro"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie in vitro sprawdzało optymalizację ekstrakcji, budowę i aktywność przeciwzakrzepową kwaśnych polisacharydów z uszaka.","en":"The in vitro study examined extraction optimisation, structural characterisation and anticoagulant activity of acidic polysaccharides from wood ear."},"sourceId":"9.5","status":"ok"},{"key":"pmid-35956781","pmid":"35956781","doi":"10.3390/molecules27154831","url":"https://doi.org/10.3390/molecules27154831","permalink":"https://alohafungi.com/nauka#pmid-35956781","permalinkEn":"https://alohafungi.com/en/nauka#pmid-35956781","title":"A Novel Polysaccharide from Auricularia Auricula Alleviates Thrombosis Induced by Carrageenan in Mice","author":"Bian C. et al.","year":2022,"journal":"Molecules","species":["auricularia"],"type":{"pl":"badanie zwierzęce (myszy)","en":"animal study (mice)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie na myszach sprawdzało, czy nowy polisacharyd z Auricularia auricula łagodzi zakrzepicę wywołaną karageniną.","en":"The mouse study examined whether a novel polysaccharide from Auricularia auricula alleviates carrageenan-induced thrombosis."},"sourceId":"9.6","status":"ok"},{"key":"pmid-24015062","pmid":"24015062","doi":"10.4489/MYCO.2007.35.1.016","url":"https://doi.org/10.4489/MYCO.2007.35.1.016","permalink":"https://alohafungi.com/nauka#pmid-24015062","permalinkEn":"https://alohafungi.com/en/nauka#pmid-24015062","title":"Hypolipidemic Effects of Biopolymers Extracted from Auricularia auricula-judae in Dietary-induced Hyperlipidemic Rats","author":"Jeong H. et al.","year":2007,"journal":"Mycobiology","species":["auricularia"],"type":{"pl":"badanie zwierzęce (szczury)","en":"animal study (rats)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie na szczurach z hiperlipidemią dietetyczną sprawdzało działanie hipolipemizujące biopolimerów z uszaka.","en":"The study in diet-induced hyperlipidemic rats examined the hypolipidemic effects of biopolymers from wood ear."},"sourceId":"9.7","status":"ok"},{"key":"pmid-23572806","pmid":"23572806","doi":"10.1007/s13197-010-0196-9","url":"https://doi.org/10.1007/s13197-010-0196-9","permalink":"https://alohafungi.com/nauka#pmid-23572806","permalinkEn":"https://alohafungi.com/en/nauka#pmid-23572806","title":"Hypocholesterolemic effects of Auricularia auricula ethanol extract in ICR mice","author":"Chen G. et al.","year":2011,"journal":"Journal of Food Science and Technology","species":["auricularia"],"type":{"pl":"badanie zwierzęce (myszy ICR)","en":"animal study (ICR mice)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie na myszach ICR sprawdzało działanie obniżające cholesterol ekstraktu etanolowego z Auricularia auricula.","en":"The study in ICR mice examined the cholesterol-lowering effect of an Auricularia auricula ethanol extract."},"sourceId":"9.8","status":"ok"},{"key":"pmid-23909573","pmid":"23909573","doi":"10.1111/1750-3841.12226","url":"https://doi.org/10.1111/1750-3841.12226","permalink":"https://alohafungi.com/nauka#pmid-23909573","permalinkEn":"https://alohafungi.com/en/nauka#pmid-23909573","title":"Chemical properties of a polysaccharide purified from solid-state fermentation of Auricularia auricula as a hypolipidemic agent","author":"Zeng F. et al.","year":2013,"journal":"Journal of Food Science","species":["auricularia"],"type":{"pl":"chemia + zwierzęce (myszy)","en":"chemistry + animal (mice)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie łączyło chemię z modelem mysim, sprawdzając właściwości polisacharydu oczyszczonego z fermentacji w stanie stałym jako środka hipolipemizującego.","en":"The study combined chemistry with a mouse model, examining the properties of a polysaccharide purified from solid-state fermentation as a hypolipidemic agent."},"sourceId":"9.9","status":"ok"},{"key":"pmid-9836425","pmid":"9836425","doi":"10.1271/bbb.62.1898","url":"https://doi.org/10.1271/bbb.62.1898","permalink":"https://alohafungi.com/nauka#pmid-9836425","permalinkEn":"https://alohafungi.com/en/nauka#pmid-9836425","title":"Hypoglycemic effect of water-soluble polysaccharide on genetically diabetic KK-Ay mice","author":"Yuan Z. et al.","year":1998,"journal":"Bioscience, Biotechnology, and Biochemistry","species":["auricularia"],"type":{"pl":"badanie zwierzęce (myszy KK-Ay)","en":"animal study (KK-Ay mice)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie na genetycznie cukrzycowych myszach KK-Ay sprawdzało działanie hipoglikemizujące wodnorozpuszczalnego polisacharydu z uszaka.","en":"The study in genetically diabetic KK-Ay mice examined the hypoglycaemic effect of a water-soluble polysaccharide from wood ear."},"sourceId":"9.10","status":"ok"},{"key":"pmid-34505615","pmid":"34505615","doi":"10.1039/d1fo02022f","url":"https://doi.org/10.1039/d1fo02022f","permalink":"https://alohafungi.com/nauka#pmid-34505615","permalinkEn":"https://alohafungi.com/en/nauka#pmid-34505615","title":"Hypoglycemic effects of Auricularia auricula polysaccharides on high fat diet and streptozotocin-induced diabetic mice","author":"Liu N. et al.","year":2021,"journal":"Food & Function","species":["auricularia"],"type":{"pl":"badanie zwierzęce (myszy)","en":"animal study (mice)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie w modelu myszy z cukrzycą wywołaną dietą wysokotłuszczową i streptozotocyną sprawdzało działanie hipoglikemizujące polisacharydów z Auricularia auricula.","en":"The study in high-fat-diet and streptozotocin-induced diabetic mice examined the hypoglycaemic effect of Auricularia auricula polysaccharides."},"sourceId":"9.11","status":"ok"},{"key":"pmid-30706914","pmid":"30706914","doi":"10.1039/c8fo01624k","url":"https://doi.org/10.1039/c8fo01624k","permalink":"https://alohafungi.com/nauka#pmid-30706914","permalinkEn":"https://alohafungi.com/en/nauka#pmid-30706914","title":"Characterization of natural melanin from Auricularia auricula and its hepatoprotective effect on acute alcohol liver injury in mice","author":"Hou R. et al.","year":2019,"journal":"Food & Function","species":["auricularia"],"type":{"pl":"badanie zwierzęce (myszy)","en":"animal study (mice)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie na myszach sprawdzało budowę naturalnej melaniny z Auricularia auricula i jej działanie ochronne na wątrobę przy ostrym uszkodzeniu alkoholowym.","en":"The mouse study examined the characterisation of natural melanin from Auricularia auricula and its hepatoprotective effect against acute alcohol-induced liver injury."},"sourceId":"9.12","status":"ok"},{"key":"pmid-31763027","pmid":"31763027","doi":"10.1002/fsn3.1239","url":"https://doi.org/10.1002/fsn3.1239","permalink":"https://alohafungi.com/nauka#pmid-31763027","permalinkEn":"https://alohafungi.com/en/nauka#pmid-31763027","title":"Comprehensive utilization of edible mushroom Auricularia auricula waste residue: melanin extraction","author":"Liu X. et al.","year":2019,"journal":"Food Science & Nutrition","species":["auricularia"],"type":{"pl":"in vitro / chemia","en":"in vitro / chemistry"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie chemiczne/in vitro sprawdzało ekstrakcję melaniny z odpadów pofermentacyjnych Auricularia auricula.","en":"The chemistry/in vitro study examined melanin extraction from Auricularia auricula waste residue."},"sourceId":"9.13","status":"ok"},{"key":"pmid-35419841","pmid":"35419841","doi":"10.1002/jobm.202100670","url":"https://doi.org/10.1002/jobm.202100670","permalink":"https://alohafungi.com/nauka#pmid-35419841","permalinkEn":"https://alohafungi.com/en/nauka#pmid-35419841","title":"Studies on the biosynthetic pathways of melanin in Auricularia auricula","author":"Ma Z. et al.","year":2022,"journal":"Journal of Basic Microbiology","species":["auricularia"],"type":{"pl":"in vitro (biosynteza)","en":"in vitro (biosynthesis)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie in vitro sprawdzało szlaki biosyntezy melaniny w Auricularia auricula.","en":"The in vitro study examined the biosynthetic pathways of melanin in Auricularia auricula."},"sourceId":"9.14","status":"ok"},{"key":"pmid-39968271","pmid":"39968271","doi":"10.7762/cnr.2025.14.1.7","url":"https://pubmed.ncbi.nlm.nih.gov/39968271/","permalink":"https://alohafungi.com/nauka#pmid-39968271","permalinkEn":"https://alohafungi.com/en/nauka#pmid-39968271","title":"Effects of the Intestinal Status and Clinical Factors of Korean Middle-Aged People Through the Consumption of Functional Foods Containing Auricularia auricula-judae Powder","author":"Son E.H. et al.","year":2025,"journal":"Clinical Nutrition Research","species":["auricularia"],"type":{"pl":"RCT otwarte (bez zaślepienia), kontrola maltodekstryna · pierwsze badanie na ludziach dla uszaka","en":"open-label RCT (no blinding), maltodextrin control · the first human study found for wood ear"},"n":{"pl":"50 osób (24/26)","en":"50 people (24/26)"},"evidenceLevel":"D","preclinical":false,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Sprawdzano 8 tygodni spożywania żywności funkcjonalnej z proszkiem uszaka 2× dziennie wobec kontroli, mierząc skład ciała, obwód talii, profil lipidowy, spożycie błonnika, skale zaparć (CAS, ROME II) i mikrobiotę jelitową u koreańskich dorosłych w średnim wieku. Badanie otwarte (formalnie randomizowane, ale bez zaślepienia). Autorzy wskazali małą próbę, brak danych długoterminowych, brak oceny zależności od dawki.","en":"The study examined 8 weeks of consuming a functional food with wood ear powder twice daily versus a control, measuring body composition, waist circumference, lipid profile, fibre intake, constipation scales (CAS, ROME II) and gut microbiota in Korean middle-aged adults. Open-label study (formally randomised but unblinded). The authors noted a small sample, no long-term data, and no dose-dependence assessment."},"sourceId":"9.15","status":"ok"},{"key":"pmid-20083182","pmid":"20083182","doi":"10.1016/j.jep.2010.01.032","url":"https://pubmed.ncbi.nlm.nih.gov/20083182/","permalink":"https://alohafungi.com/nauka#pmid-20083182","permalinkEn":"https://alohafungi.com/en/nauka#pmid-20083182","title":"Diuretic activity and kidney medulla AQP1, AQP2, AQP3, V2R expression of the aqueous extract of sclerotia of Polyporus umbellatus FRIES in normal rats","author":"Zhang G. et al.","year":2010,"journal":"Journal of Ethnopharmacology","species":["polyporus"],"type":{"pl":"badanie zwierzęce (szczury)","en":"animal study (rats)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie na szczurach sprawdzało aktywność moczopędną oraz ekspresję akwaporyn (AQP1-3) i receptora V2R w rdzeniu nerki po podaniu Polyporus umbellatus.","en":"The rat study examined diuretic activity and the expression of aquaporins (AQP1-3) and the V2 receptor in the kidney medulla after Polyporus umbellatus administration."},"sourceId":"10.1","status":"ok"},{"key":"pmid-21213404","pmid":"21213404","doi":"10.1142/S0192415X11008713","url":"https://pubmed.ncbi.nlm.nih.gov/21213404/","permalink":"https://alohafungi.com/nauka#pmid-21213404","permalinkEn":"https://alohafungi.com/en/nauka#pmid-21213404","title":"Inhibition of urinary bladder carcinogenesis by aqueous extract of sclerotia of Polyporus umbellatus","author":"Zhang G. et al.","year":2011,"journal":"American Journal of Chinese Medicine","species":["polyporus"],"type":{"pl":"badanie zwierzęce","en":"animal study"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie na zwierzętach sprawdzało, czy wodny ekstrakt ze sklerocjum Polyporus umbellatus hamuje karcynogenezę pęcherza moczowego.","en":"The animal study examined whether an aqueous extract of Polyporus umbellatus sclerotium inhibits urinary bladder carcinogenesis."},"sourceId":"10.2","status":"ok"},{"key":"pmid-20673883","pmid":"20673883","doi":"10.1016/j.cellimm.2010.07.002","url":"https://pubmed.ncbi.nlm.nih.gov/20673883/","permalink":"https://alohafungi.com/nauka#pmid-20673883","permalinkEn":"https://alohafungi.com/en/nauka#pmid-20673883","title":"Polysaccharide purified from Polyporus umbellatus mycelia promotes maturation of murine bone marrow-derived dendritic cells via TLR4","author":"Li X. et al.","year":2010,"journal":"Cellular Immunology","species":["polyporus"],"type":{"pl":"in vitro (mysie komórki dendrytyczne)","en":"in vitro (mouse dendritic cells)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie in vitro sprawdzało aktywację mysich komórek dendrytycznych przez oczyszczony polisacharyd z Polyporus umbellatus za pośrednictwem receptora TLR4.","en":"The in vitro study examined the activation of mouse dendritic cells by a purified Polyporus umbellatus polysaccharide via the TLR4 receptor."},"sourceId":"10.3","status":"ok"},{"key":"pmid-20600759","pmid":"20600759","doi":"10.1016/j.jep.2010.06.028","url":"https://pubmed.ncbi.nlm.nih.gov/20600759/","permalink":"https://alohafungi.com/nauka#pmid-20600759","permalinkEn":"https://alohafungi.com/en/nauka#pmid-20600759","title":"TLR4-mediated activation of macrophages by the polysaccharide fraction from Polyporus umbellatus","author":"Li X., Xu W.","year":2011,"journal":"Journal of Ethnopharmacology","species":["polyporus"],"type":{"pl":"in vitro (makrofagi)","en":"in vitro (macrophages)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie in vitro sprawdzało aktywację makrofagów przez frakcję polisacharydową z Polyporus umbellatus za pośrednictwem receptora TLR4.","en":"The in vitro study examined macrophage activation by a Polyporus umbellatus polysaccharide fraction via the TLR4 receptor."},"sourceId":"10.4","status":"ok"},{"key":"pmid-25542103","pmid":"25542103","doi":"10.1016/j.carbpol.2014.11.012","url":"https://pubmed.ncbi.nlm.nih.gov/25542103/","permalink":"https://alohafungi.com/nauka#pmid-25542103","permalinkEn":"https://alohafungi.com/en/nauka#pmid-25542103","title":"Efficacy of Zhuling polyporus polysaccharide with BCG to inhibit bladder carcinoma","author":"Zhang G.W. et al.","year":2015,"journal":"Carbohydrate Polymers","species":["polyporus"],"type":{"pl":"badanie zwierzęce","en":"animal study"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie na zwierzętach sprawdzało skuteczność polisacharydu z żagwi (Zhuling) w połączeniu ze szczepionką BCG w hamowaniu raka pęcherza moczowego.","en":"The animal study examined the efficacy of Zhuling (Polyporus) polysaccharide combined with BCG vaccine in inhibiting bladder carcinoma."},"sourceId":"10.5","status":"ok"},{"key":"pmid-1576664","pmid":"1576664","doi":"10.1248/cpb.40.143","url":"https://pubmed.ncbi.nlm.nih.gov/1576664/","permalink":"https://alohafungi.com/nauka#pmid-1576664","permalinkEn":"https://alohafungi.com/en/nauka#pmid-1576664","title":"Studies on constituents of fruit body of Polyporus umbellatus and their cytotoxic activity","author":"Ohsawa T. et al.","year":1992,"journal":"Chemical & Pharmaceutical Bulletin","species":["polyporus"],"type":{"pl":"chemia strukturalna + in vitro (linia L1210)","en":"structural chemistry + in vitro (L1210 line)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Chemia izolowała siedem nowych związków (polyporusterony A-G) z owocnika i testowała cytotoksyczność in vitro.","en":"The chemistry study isolated seven new compounds (polyporusterones A-G) from the fruiting body and tested cytotoxicity in vitro."},"sourceId":"10.6","status":"ok"},{"key":"pmid-15187435","pmid":"15187435","doi":"10.1248/bpb.27.867","url":"https://pubmed.ncbi.nlm.nih.gov/15187435/","permalink":"https://alohafungi.com/nauka#pmid-15187435","permalinkEn":"https://alohafungi.com/en/nauka#pmid-15187435","title":"An anti-aldosteronic diuretic component (drain dampness) in Polyporus sclerotium","author":"Yuan D. et al.","year":2004,"journal":"Biological & Pharmaceutical Bulletin","species":["polyporus"],"type":{"pl":"izolacja związku + model zwierzęcy","en":"compound isolation + animal model"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie izolowało związek o działaniu antyaldosteronowym (moczopędnym) ze sklerocjum Polyporus i testowało go w modelu zwierzęcym.","en":"The study isolated an anti-aldosteronic (diuretic) compound from Polyporus sclerotium and tested it in an animal model."},"sourceId":"10.7","status":"ok"},{"key":"pmid-23811047","pmid":"23811047","doi":"10.1016/j.jep.2013.06.031","url":"https://pubmed.ncbi.nlm.nih.gov/23811047/","permalink":"https://alohafungi.com/nauka#pmid-23811047","permalinkEn":"https://alohafungi.com/en/nauka#pmid-23811047","title":"Traditional uses, phytochemistry, pharmacology, pharmacokinetics and quality control of Polyporus umbellatus: a review","author":"Zhao Y.Y.","year":2013,"journal":"Journal of Ethnopharmacology","species":["polyporus"],"type":{"pl":"przegląd narracyjny","en":"narrative review"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd zbierał wiedzę o tradycyjnym stosowaniu, fitochemii, farmakologii i kontroli jakości Polyporus umbellatus; autor zaznacza, że badania są w większości przedkliniczne.","en":"The review collected knowledge on the traditional use, phytochemistry, pharmacology and quality control of Polyporus umbellatus; the author notes that the studies are mostly preclinical."},"sourceId":"10.8","status":"ok"},{"key":"pmid-39885918","pmid":"39885918","doi":"10.1016/j.fochx.2025.102161","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11780138/","permalink":"https://alohafungi.com/nauka#pmid-39885918","permalinkEn":"https://alohafungi.com/en/nauka#pmid-39885918","title":"A systematic review of advances in preparation, structures, bioactivities and structure-activity relationships of Polyporus umbellatus polysaccharides","author":"Gao W. et al.","year":2025,"journal":"Food Chemistry: X","species":["polyporus"],"type":{"pl":"przegląd systematyczny chemii i bioaktywności przedklinicznej (z zastrzeżeniem)","en":"systematic review of chemistry and preclinical bioactivity (qualified)"},"n":{"pl":"156 i 28 pacjentów z WZW B (lek farmaceutyczny PUP, lata 90., bez randomizacji i zaślepienia)","en":"156 and 28 hepatitis B patients (the PUP pharmaceutical drug, 1990s, no randomisation or blinding)"},"evidenceLevel":"B","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd zbierał ponad 50 lat badań nad ekstrakcją, strukturą i bioaktywnością polisacharydów Polyporus, z jednym odniesieniem do dwóch historycznych, otwartych badań chińskiego leku PUP u pacjentów z WZW B. To NIE są RCT ani badania nad suplementem diety; przegląd jest systematyczny w zakresie chemii, nie skuteczności klinicznej, stąd poziom B z zastrzeżeniem.","en":"The review collected over 50 years of research on the extraction, structure and bioactivity of Polyporus polysaccharides, with one reference to two historical, open-label studies of the Chinese PUP drug in hepatitis B patients. These are NOT RCTs or dietary-supplement studies; the review is systematic regarding chemistry, not clinical efficacy, hence a qualified level B."},"sourceId":"10.12","status":"ok"},{"key":"pmid-38873452","pmid":"38873452","doi":"10.1002/fsn3.4048","url":"https://pubmed.ncbi.nlm.nih.gov/38873452/","permalink":"https://alohafungi.com/nauka#pmid-38873452","permalinkEn":"https://alohafungi.com/en/nauka#pmid-38873452","title":"Effects of a combination of Poria Cocos, Ziziphus spinose, and GABA on sleep quality and skin health","author":"Hao Y., Song W., Qu L.","year":2024,"journal":"Food Science & Nutrition","species":["pornatka"],"type":{"pl":"RCT, podwójnie zaślepione, placebo (kombinacja 3 składników)","en":"RCT, double-blind, placebo-controlled (3-ingredient combination)"},"n":{"pl":"70 osób, 4 tygodnie","en":"70 people, 4 weeks"},"evidenceLevel":"C","preclinical":false,"placebo":true,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Sprawdzano 4-tygodniowe przyjmowanie kombinacji Poria cocos + Ziziphus spinosa + GABA na wyniki kwestionariusza PSQI, całkowity czas snu oraz parametry skóry u 70 osób ze skargami na sen. Trzy składniki naraz, efektu nie da się przypisać samej pornatce.","en":"The study examined 4 weeks of a Poria cocos + Ziziphus spinosa + GABA combination on PSQI questionnaire scores, total sleep time and skin parameters in 70 people with sleep complaints. Three ingredients at once; the effect cannot be attributed to poria alone."},"sourceId":"11.1","status":"ok"},{"key":"pmid-37836526","pmid":"37836526","doi":"10.3390/nu15194242","url":"https://pubmed.ncbi.nlm.nih.gov/37836526/","permalink":"https://alohafungi.com/nauka#pmid-37836526","permalinkEn":"https://alohafungi.com/en/nauka#pmid-37836526","title":"Efficacy of Poria Cocos Extract on Sleep Quality Enhancement","author":"Kim H. et al.","year":2023,"journal":"Nutrients","species":["pornatka"],"type":{"pl":"badanie kliniczne monoterapii (bez wzmianki o randomizacji/placebo w abstrakcie)","en":"monotherapy clinical study (no mention of randomisation/placebo in the abstract)"},"n":{"pl":"21 osób, 800 mg wieczorem","en":"21 people, 800 mg in the evening"},"evidenceLevel":"D","preclinical":false,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Sprawdzano wpływ ekstraktu (800 mg wieczorem) na parametry snu mierzone kwestionariuszem i polisomnografią u 21 osób z bezsennością (średni wiek ok. 55 lat). Abstrakt nie precyzuje randomizacji ani grupy placebo, bardzo mała próba.","en":"The study examined the effect of the extract (800 mg in the evening) on sleep parameters measured by questionnaire and polysomnography in 21 people with insomnia (mean age approx. 55). The abstract does not specify randomisation or a placebo group; very small sample."},"sourceId":"11.2","status":"ok"},{"key":"doi-10-3892-etm-2022-11484","pmid":null,"doi":"10.3892/etm.2022.11484","url":"https://doi.org/10.3892/etm.2022.11484","permalink":"https://alohafungi.com/nauka#doi-10-3892-etm-2022-11484","permalinkEn":"https://alohafungi.com/en/nauka#doi-10-3892-etm-2022-11484","title":"Pharmacological profiles and therapeutic applications of pachymic acid","author":"Wei C. et al.","year":2022,"journal":"Experimental and Therapeutic Medicine","species":["pornatka"],"type":{"pl":"przegląd narracyjny","en":"narrative review"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd narracyjny omawiał profile farmakologiczne i zastosowania terapeutyczne kwasu pachymowego (związku z pornatki).","en":"The narrative review discussed the pharmacological profiles and therapeutic applications of pachymic acid (a compound from poria)."},"sourceId":"11.3","status":"unknown"},{"key":"pmid-21347995","pmid":"21347995","doi":"10.1055/s-0030-1270823","url":"https://doi.org/10.1055/s-0030-1270823","permalink":"https://alohafungi.com/nauka#pmid-21347995","permalinkEn":"https://alohafungi.com/en/nauka#pmid-21347995","title":"Chemical Constituents and Pharmacological Properties of Poria cocos","author":"Rios J.L.","year":2011,"journal":"Planta Medica","species":["pornatka"],"type":{"pl":"przegląd narracyjny","en":"narrative review"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd narracyjny omawiał skład chemiczny i właściwości farmakologiczne Poria cocos.","en":"The narrative review discussed the chemical composition and pharmacological properties of Poria cocos."},"sourceId":"11.4","status":"ok"},{"key":"doi-10-3390-life11020111","pmid":null,"doi":"10.3390/life11020111","url":"https://doi.org/10.3390/life11020111","permalink":"https://alohafungi.com/nauka#doi-10-3390-life11020111","permalinkEn":"https://alohafungi.com/en/nauka#doi-10-3390-life11020111","title":"The Lanostane Triterpenoids in Poria cocos Play Beneficial Roles in Immunoregulatory Activity","author":"Chao C.L. et al.","year":2021,"journal":"Life","species":["pornatka"],"type":{"pl":"in vitro / przegląd aktywności","en":"in vitro / activity review"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd i badanie in vitro omawiały rolę triterpenoidów lanostanowych z Poria cocos w aktywności immunoregulacyjnej.","en":"The review and in vitro study discussed the role of lanostane triterpenoids from Poria cocos in immunoregulatory activity."},"sourceId":"11.5","status":"unknown"},{"key":"doi-10-1155-2011-128402","pmid":null,"doi":"10.1155/2011/128402","url":"https://doi.org/10.1155/2011/128402","permalink":"https://alohafungi.com/nauka#doi-10-1155-2011-128402","permalinkEn":"https://alohafungi.com/en/nauka#doi-10-1155-2011-128402","title":"Anti-Hyperglycemic Properties of Crude Extract and Triterpenes from Poria cocos","author":"Li T.H. et al.","year":2011,"journal":"Evidence-Based Complementary and Alternative Medicine","species":["pornatka"],"type":{"pl":"badanie mechanistyczne przedkliniczne","en":"preclinical mechanistic study"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Badanie przedkliniczne, mechanistyczne sprawdzało działanie przeciwhiperglikemiczne surowego ekstraktu i triterpenów z Poria cocos.","en":"The preclinical, mechanistic study examined the anti-hyperglycaemic properties of crude extract and triterpenes from Poria cocos."},"sourceId":"11.6","status":"unknown"},{"key":"doi-10-3389-fcell-2025-1547633","pmid":null,"doi":"10.3389/fcell.2025.1547633","url":"https://doi.org/10.3389/fcell.2025.1547633","permalink":"https://alohafungi.com/nauka#doi-10-3389-fcell-2025-1547633","permalinkEn":"https://alohafungi.com/en/nauka#doi-10-3389-fcell-2025-1547633","title":"Progress in bioactivity, chemical composition and pharmacological mechanism of Wolfiporia cocos","author":"Li Z. et al.","year":2025,"journal":"Frontiers in Cell and Developmental Biology","species":["pornatka"],"type":{"pl":"przegląd narracyjny","en":"narrative review"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Przegląd narracyjny omawiał postępy w badaniach nad bioaktywnością, składem chemicznym i mechanizmem farmakologicznym Wolfiporia cocos.","en":"The narrative review discussed progress in research on the bioactivity, chemical composition and pharmacological mechanism of Wolfiporia cocos."},"sourceId":"11.7","status":"unknown"},{"key":"pmid-35642970","pmid":"35642970","doi":"","url":"https://pubmed.ncbi.nlm.nih.gov/35642970/","permalink":"https://alohafungi.com/nauka#pmid-35642970","permalinkEn":"https://alohafungi.com/en/nauka#pmid-35642970","title":"Poria cocos water-soluble polysaccharide modulates anxiety-like behavior induced by sleep deprivation","author":"Zhang D.D. et al.","year":2022,"journal":"Food & Function","species":["pornatka"],"type":{"pl":"badanie zwierzęce (szczury)","en":"animal study (rats)"},"n":{"pl":"nie dotyczy","en":"not applicable"},"evidenceLevel":"E","preclinical":true,"placebo":null,"caseReport":false,"subspecies":null,"whatWasTested":{"pl":"Sprawdzano wpływ wodnorozpuszczalnego polisacharydu na zachowania lękopodobne po deprywacji snu, mikrobiotę jelitową i szlak TNF-α/NF-κB u szczurów.","en":"The study examined the effect of a water-soluble polysaccharide on anxiety-like behaviour after sleep deprivation, gut microbiota, and the TNF-α/NF-κB pathway in rats."},"sourceId":"11.8","status":"ok"}],"statusCheckedAt":"2026-09-21","statusSummary":{"ok":126,"erratum":0,"retracted":0,"unknown":12}}